Benjamin Thoreau, Arthur Renaud, Philippe Chafey, Guilhem Clary, Morgane Le Gall, Cédric Broussard, Odile Launay, David Launay, Eric Hachulla, Christophe Deligny, Alban-Elouen Baruteau, Anaïs Vallet-Pichard, Benjamin Chaigne, Azzeddine Yaici, Olivier Sitbon, David Montani, Marc Humbert, Luc Mouthon
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引用次数: 0
Abstract
Autoantibody profiles in HIV-associated pulmonary arterial hypertension (HIV-PAH) remain poorly characterized. Using a validated proteomic pipeline (two-dimensional immunoblot, mass spectrometry, ELISA), we compared 20 HIV-PAH patients with 20 HIV controls without PAH. Anti-annexin A5 (AnxA5) autoantibodies were present in 55% of HIV-PAH patients versus 0% of controls (P < .001) and anti-14-3-3ε in 35% versus 5% (P = .04), despite comparable HIV duration, CD4 counts, and virological control. Both remained associated with PAH after adjustment for coinfections. These autoantibodies mirror those described in connective-tissue-disease-PAH, suggesting a possible overlap in autoimmune features and a research biomarker warranting prospective validation.
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