EXPRESS: Letter to the Editor Regarding "Much ado about eating: Intermittent fasting and post-stroke neuroprotection".

IF 4.5

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2026-10-20 DOI:10.1177/0271678X261501655

Guilherme Bezerra Carneiro, Carolina Moreno Pace, Eberval Gadelha Figueiredo

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Abstract

Vemuganti and colleagues highlight intermittent fasting (IF)'s neuroprotective potential post-stroke via autophagy and mitochondrial biogenesis. However, clinical translation faces hurdles in metabolically vulnerable patients. This letter critiques IF's bedside applicability, emphasizing post-stroke catabolic stress, dysphagia (~50% cases), sarcopenia risk, and cardiovascular concerns. Recent evidence links short eating windows to higher mortality, countering IF benefits. The obesity paradox suggests nutritional reserves aid survival. Strategies: protein-prioritized planning, dysphagia screening, dietitian monitoring, and supplements. Until RCTs confirm safety/efficacy, prioritize nutritional adequacy. Preclinical insights warrant study.Keywords: dysphagia, intermittent fasting, neuroprotection, obesity paradox, sarcopenia.

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《快报》：致编辑的信，关于“进食的烦恼：间歇性禁食和中风后的神经保护”。

Vemuganti及其同事强调间歇性禁食（IF）通过自噬和线粒体生物发生在中风后具有神经保护潜力。然而，临床翻译在代谢易感患者中面临障碍。这封信批评了IF的床边适用性，强调中风后分解代谢应激、吞咽困难（约50%病例）、肌肉减少风险和心血管问题。最近的证据表明，进食时间短与死亡率高有关，这与IF的好处背道而驰。肥胖悖论表明，营养储备有助于生存。策略：蛋白质优先计划，吞咽困难筛查，营养师监测和补充。在随机对照试验确认安全性/有效性之前，优先考虑营养充足。临床前观察值得研究。关键词：吞咽困难，间歇性禁食，神经保护，肥胖悖论，肌肉减少症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

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