Wanqiong Yuan, Jing Hang, Jialin Jia, Jie Huang, Xuanqi Zheng, Huan Wang, Tong Wu, Hao Liu, Junxiong Zhu, Chenggui Zhang, Jinwen He, Yundi Zhang, Hong Wang, Xin Xiong, Na He, Haofan Bai, Jiamin Yan, Huijie Leng, Weili Zhu, Yingsheng Xu, Jie Shi, Chunli Song
{"title":"Vitamin K2 ameliorates pregnancy- and lactation-associated osteopenia and postpartum depression.","authors":"Wanqiong Yuan, Jing Hang, Jialin Jia, Jie Huang, Xuanqi Zheng, Huan Wang, Tong Wu, Hao Liu, Junxiong Zhu, Chenggui Zhang, Jinwen He, Yundi Zhang, Hong Wang, Xin Xiong, Na He, Haofan Bai, Jiamin Yan, Huijie Leng, Weili Zhu, Yingsheng Xu, Jie Shi, Chunli Song","doi":"10.1002/imt2.70180","DOIUrl":null,"url":null,"abstract":"<p><p>Vitamin K2 (VitK2) supplementation ameliorates comorbid pregnancy- and lactation-associated osteopenia (PLO) and postpartum depression (PPD). These improvements are accompanied by reduced relative abundance of <i>Bacteroides uniformis</i> (<i>B</i>. <i>uniformis</i>) and lower serum deoxycholic acid (DCA) levels. DCA inhibits osteoblast differentiation, promotes osteoclast differentiation, and contributes to an imbalance between hippocampal glutamatergic and GABAergic signaling. Maternal VitK2 supplementation also improves offspring cognition. These findings suggest that modulation of the gut microbiota-bile acid axis may contribute to the beneficial effects of VitK2, supporting the potential of VitK2 as a therapeutic agent for PLO and PPD.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":" ","pages":"e70180"},"PeriodicalIF":44.4000,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679786/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"iMeta","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/imt2.70180","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vitamin K2 (VitK2) supplementation ameliorates comorbid pregnancy- and lactation-associated osteopenia (PLO) and postpartum depression (PPD). These improvements are accompanied by reduced relative abundance of Bacteroides uniformis (B. uniformis) and lower serum deoxycholic acid (DCA) levels. DCA inhibits osteoblast differentiation, promotes osteoclast differentiation, and contributes to an imbalance between hippocampal glutamatergic and GABAergic signaling. Maternal VitK2 supplementation also improves offspring cognition. These findings suggest that modulation of the gut microbiota-bile acid axis may contribute to the beneficial effects of VitK2, supporting the potential of VitK2 as a therapeutic agent for PLO and PPD.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
