Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.

IF 2.6 3区医学 Q2 MEDICINE, GENERAL & INTERNAL

Patient preference and adherence Pub Date : 2026-10-15 eCollection Date: 2026-01-01 DOI:10.2147/PPA.S643084

Wei Wang, Dan Zhou, Haoping Zhao, Liling Yang, Jiwei Wang

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引用次数: 0

Abstract

Purpose: Inflammatory bowel disease (IBD) requires long-term self-management, yet evidence on patients' knowledge, attitude, and practice (KAP) remains limited. This study assessed KAP levels in patients with IBD, identified factors associated with overall KAP levels and explored whether attitude mediates the relationship between knowledge and practice.

Patients and methods: A cross-sectional survey was conducted among patients with IBD attending the Second Affiliated Hospital of Nanchang University from June to December 2025. Data were collected using a study-specific questionnaire covering sociodemographic characteristics and KAP dimensions. Spearman correlation analysis, multivariable linear regression, and structural equation modeling with bootstrap resampling were performed.

Results: A total of 520 patients were included. The mean knowledge, attitude, and practice scores were 3.97 ± 1.98 (range: 0-10), 24.43 ± 3.58 (range: 8-40), and 28.82 ± 4.41 (range: 8-40), respectively. Knowledge item correct response rates ranged from 29.4% to 48.3%, indicating limited disease-related knowledge. Knowledge was positively correlated with attitude (r = 0.190, P < 0.01) and practice (r = 0.223, P < 0.001), while attitude was positively correlated with practice (r = 0.346, P < 0.001). In multivariable analysis, female sex was associated with lower total KAP scores, whereas higher monthly family income was associated with higher scores. Former and current smoking and drinking were associated with lower total KAP scores, while having 2-3 comorbidities was associated with higher scores. Attitude did not significantly mediate the knowledge-practice relationship.

Conclusions: Patients with IBD showed limited knowledge, relatively unfavorable attitude, and moderately proactive practice. Knowledge and attitude were both positively associated with practice, but attitude did not significantly mediate the association between knowledge and practice. The potential benefits of educational, behavioral, and psychosocial interventions require evaluation in prospective or interventional studies.

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炎症性肠病的知识、态度和实践：相关因素和态度的中介作用。

目的：炎症性肠病（IBD）需要长期的自我管理，但关于患者知识、态度和实践（KAP）的证据仍然有限。本研究评估了IBD患者的KAP水平，确定了与总体KAP水平相关的因素，并探讨了态度是否介导了知识与实践之间的关系。患者与方法：对南昌大学第二附属医院2025年6月至12月IBD患者进行横断面调查。数据收集使用研究特定的问卷调查，涵盖社会人口特征和KAP维度。采用Spearman相关分析、多变量线性回归和自举重采样结构方程模型。结果：共纳入520例患者。知识、态度和实践的平均得分分别为3.97±1.98分（范围0 ~ 10）、24.43±3.58分（范围8 ~ 40）和28.82±4.41分（范围8 ~ 40）。知识项正确率在29.4% ~ 48.3%之间，表明疾病相关知识有限。知识与态度（r = 0.190, P < 0.01）、实践（r = 0.223, P < 0.001）呈正相关，态度与实践（r = 0.346, P < 0.001）呈正相关。在多变量分析中，女性与较低的KAP总分相关，而较高的家庭月收入与较高的分数相关。既往和当前吸烟和饮酒与较低的KAP总分相关，而有2-3个合并症与较高的得分相关。态度对知识-实践关系没有显著的中介作用。结论：IBD患者知识有限，态度相对不利，行为较为主动。知识和态度对实践均有正向影响，但态度对知识和实践的中介作用不显著。教育、行为和社会心理干预的潜在益处需要在前瞻性或干预性研究中进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Patient preference and adherence MEDICINE, GENERAL & INTERNAL-

CiteScore

3.60

自引率

4.50%

发文量

354

审稿时长

6-12 weeks

期刊介绍： Patient Preference and Adherence is an international, peer reviewed, open access journal that focuses on the growing importance of patient preference and adherence throughout the therapeutic continuum. The journal is characterized by the rapid reporting of reviews, original research, modeling and clinical studies across all therapeutic areas. Patient satisfaction, acceptability, quality of life, compliance, persistence and their role in developing new therapeutic modalities and compounds to optimize clinical outcomes for existing disease states are major areas of interest for the journal. As of 1st April 2019, Patient Preference and Adherence will no longer consider meta-analyses for publication.