Fatigue, Anxiety and Depression 12 Months After Out-of-Hospital Cardiac Arrest: A Population Based Cohort Study.

IF 6 1区医学 Q1 CRITICAL CARE MEDICINE

Resuscitation Pub Date : 2026-10-20 DOI:10.1016/j.resuscitation.2026.111359

Daniel O Okyere, Emily Nehme, Janet Bray, Katie N Dainty, Ashanti Dantanarayana, Ziad Nehme

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引用次数: 0

Abstract

Aim: To determine the prevalence and factors associated with fatigue, anxiety, and depression 12 months after out-of-hospital cardiac arrest (OHCA); examine their associations with health-related quality of life (HRQoL) and functional recovery; and compare symptom burden with population norms.

Methods: This prospective, population-based cohort study included adults (≥18 years) who received EMS-attempted resuscitation and survived to hospital discharge following non-traumatic OHCA in Victoria, Australia, between July 2019 and June 2022. Survivors were identified from a statewide OHCA registry and completed a 12-month telephone interview. Primary outcomes were fatigue (Modified Fatigue Impact Scale), anxiety and depression (Hospital Anxiety and Depression Scale). Secondary outcomes included HRQoL (EQ-5D, SF-12), functional recovery (GOSE), living arrangement, and return to work.

Results: Of 1068 eligible 12-month survivors, 728 (68.2%) completed follow-up (median age 61 years; 555 [76.2%] male). Fatigue was reported by 35.8% (250/699), anxiety by 22.6% (162/716), and depression by 18.0% (129/716). Higher symptom burden was associated with lower EQ-5D and SF-12 scores, worse GOSE outcomes (all p<0.001) and reduced return-to-work rates. Compared with population norms, survivors reported greater fatigue (SMD 0.64; 95%CI, 0.50-0.78;p<0.001), and depression (SMD, 0.12; 95%CI, 0.02,0.21;p=0.02) but lower anxiety (SMD, -0.27; 95%CI, -0.35 to -0.18;p<0.001). In adjusted models, younger age, preexisting anxiety or depression, diabetes and initial non-shockable arrest were associated with higher symptom burden, whereas EMS-witnessed arrests were associated with lower symptom burden.

Conclusions: Fatigue, anxiety, and depression were common at 12 months after OHCA and are associated with poorer recovery. Fatigue exceeded population norms and may be an under-recognised component of cardiac arrest survivorship.

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院外心脏骤停后12个月的疲劳、焦虑和抑郁：一项基于人群的队列研究

目的：确定院外心脏骤停（OHCA） 12个月后疲劳、焦虑和抑郁的患病率及其相关因素；检查其与健康相关生活质量（HRQoL）和功能恢复的关系；并将症状负担与人群常态进行比较。方法：这项前瞻性、基于人群的队列研究包括2019年7月至2022年6月期间在澳大利亚维多利亚州接受ems -未遂复苏并在非创伤性OHCA后存活至出院的成年人（≥18岁）。幸存者是从全州OHCA登记处确定的，并完成了为期12个月的电话采访。主要结局是疲劳（修正疲劳影响量表）、焦虑和抑郁（医院焦虑抑郁量表）。次要指标包括HRQoL （EQ-5D, SF-12）、功能恢复（GOSE）、生活安排和重返工作岗位。结果：在1068名符合条件的12个月幸存者中，728名（68.2%）完成了随访（中位年龄61岁；555名（76.2%）男性）。疲劳占35.8%(250/699)，焦虑占22.6%(162/716)，抑郁占18.0%（129/716）。较高的症状负担与较低的EQ-5D和SF-12评分、较差的GOSE结果相关。结论：疲劳、焦虑和抑郁在OHCA后12个月很常见，并与较差的恢复相关。疲劳超过人群标准，可能是心脏骤停幸存者的一个未被认识到的组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Resuscitation 医学-急救医学

CiteScore

12.00

自引率

18.50%

发文量

556

审稿时长

21 days

期刊介绍： Resuscitation is a monthly international and interdisciplinary medical journal. The papers published deal with the aetiology, pathophysiology and prevention of cardiac arrest, resuscitation training, clinical resuscitation, and experimental resuscitation research, although papers relating to animal studies will be published only if they are of exceptional interest and related directly to clinical cardiopulmonary resuscitation. Papers relating to trauma are published occasionally but the majority of these concern traumatic cardiac arrest.