What Are the Impacts of Immunoglobulin a Vasculitis on Choroidal Vascularity and Subfoveal Thickness in Children.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2026-10-20 DOI:10.1080/09286586.2026.2748441

Gizem Gürbostan Soysal, Sevim Ayca Seyyar, İbrahim Edhem Yılmaz, Levent Doğan, Murat Mercanlı, Kıvanç Güngör, Ayşegül Çömez, Ayşe Tanatar

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引用次数: 0

Abstract

Purpose: To evaluate choroidal structural and vascular changes in children with Immunoglobulin A vasculitis (IgAV) using optical coherence tomography (OCT).

Methods: This prospective cross-sectional study included 90 eyes of 41 children diagnosed with IgAV and 49 age-matched healthy controls. All participants underwent comprehensive ophthalmic examination and OCT imaging. Subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) were measured.

Results: Subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) values were significantly lower in the patient group compared to the healthy group (p = 0.017, p = 0.018, respectively). SFCT and CVI were negatively correlated with disease activation and duration, respectively (r = -0.614 p < 0.001; r = -0.377 p < 0.05, respectively).

Conclusion: Children with IgAV demonstrated significantly reduced SFCT and CVI compared with healthy controls. These findings indicate the presence of choroidal structural and vascular alterations in IgAV, even in the absence of clinically apparent ocular pathology.

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免疫球蛋白a血管炎对儿童脉络膜血管和中央凹下厚度的影响。

目的：利用光学相干断层扫描（OCT）评价儿童免疫球蛋白A血管炎（IgAV）的脉络膜结构和血管变化。方法：这项前瞻性横断面研究包括41名诊断为IgAV的儿童的90只眼睛和49名年龄匹配的健康对照。所有的参与者都接受了全面的眼科检查和OCT成像。测量中央凹下脉络膜厚度（SFCT）和脉络膜血管指数（CVI）。结果：患者组中央凹下脉络膜厚度（SFCT）和脉络膜血管指数（CVI）值明显低于健康组（p = 0.017, p = 0.018）。SFCT和CVI分别与疾病激活和病程呈负相关（r = -0.614 p r = -0.377 p）。结论：与健康对照组相比，IgAV患儿SFCT和CVI显著降低。这些结果表明IgAV存在脉络膜结构和血管改变，即使在临床上没有明显的眼部病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.