Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).

IF 3.8 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2026-10-05 eCollection Date: 2026-01-01 DOI:10.3389/fpsyt.2026.1904119

Hikaru Hori, Hiroyoshi Takeuchi, Shinji Yoneda, Tadashi Shin, Yusuke Shimada, Minami Umeyama, Masato Ueno, Yoshiteru Takekita

{"title":"Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).","authors":"Hikaru Hori, Hiroyoshi Takeuchi, Shinji Yoneda, Tadashi Shin, Yusuke Shimada, Minami Umeyama, Masato Ueno, Yoshiteru Takekita","doi":"10.3389/fpsyt.2026.1904119","DOIUrl":null,"url":null,"abstract":"Background: Constipation, a common gastrointestinal disorder, impairs quality of life (QOL) and work productivity. This study evaluated constipation severity in individuals with schizophrenia, depression, and the general population and examined its impact on QOL and work productivity, as well as patient education and preferences regarding constipation management.Methods: A cross-sectional web-based survey was conducted. Assessments included the Constipation Scoring System (CSS), Short Form-8, Work Productivity and Activity Impairment questionnaire, and questions regarding prior explanations of constipation risk and changes in bowel habits. CSS scores were stratified as ≤5 and ≥6.Results: In total, 800 participants completed the survey (schizophrenia, n=200; depression, n=200; general population, n=400). CSS scores were higher in the schizophrenia and depression groups than in the general population. Multivariable regression analysis showed that schizophrenia and depression were associated with constipation severity. In the schizophrenia and depression groups, current symptom status and anxiolytic use remained independently associated with CSS scores. Across all groups, participants with CSS scores ≥6 had lower Mental Component Summary scores and higher levels of presenteeism, overall work productivity loss, and activity impairment than those with CSS scores ≤5. Approximately 30% of all participants in each of the schizophrenia and depression groups reported receiving prior explanations regarding psychotropic-related constipation risk, while 40% reported bowel-habit changes after psychotropic drug initiation.Conclusions: Constipation severity was higher in participants with schizophrenia and depression than in the general population; greater severity was associated with lower QOL and greater work productivity impairment. Routine screening, education on constipation, and patient-centered constipation management may be useful clinical approaches for addressing constipation and its associated burden in these populations.Trial registration: This study was registered with the University Hospital Medical Information Network (UMIN000058981).","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"17 ","pages":"1904119"},"PeriodicalIF":3.8000,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679139/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpsyt.2026.1904119","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Constipation, a common gastrointestinal disorder, impairs quality of life (QOL) and work productivity. This study evaluated constipation severity in individuals with schizophrenia, depression, and the general population and examined its impact on QOL and work productivity, as well as patient education and preferences regarding constipation management.

Methods: A cross-sectional web-based survey was conducted. Assessments included the Constipation Scoring System (CSS), Short Form-8, Work Productivity and Activity Impairment questionnaire, and questions regarding prior explanations of constipation risk and changes in bowel habits. CSS scores were stratified as ≤5 and ≥6.

Results: In total, 800 participants completed the survey (schizophrenia, n=200; depression, n=200; general population, n=400). CSS scores were higher in the schizophrenia and depression groups than in the general population. Multivariable regression analysis showed that schizophrenia and depression were associated with constipation severity. In the schizophrenia and depression groups, current symptom status and anxiolytic use remained independently associated with CSS scores. Across all groups, participants with CSS scores ≥6 had lower Mental Component Summary scores and higher levels of presenteeism, overall work productivity loss, and activity impairment than those with CSS scores ≤5. Approximately 30% of all participants in each of the schizophrenia and depression groups reported receiving prior explanations regarding psychotropic-related constipation risk, while 40% reported bowel-habit changes after psychotropic drug initiation.

Conclusions: Constipation severity was higher in participants with schizophrenia and depression than in the general population; greater severity was associated with lower QOL and greater work productivity impairment. Routine screening, education on constipation, and patient-centered constipation management may be useful clinical approaches for addressing constipation and its associated burden in these populations.

Trial registration: This study was registered with the University Hospital Medical Information Network (UMIN000058981).

查看原文本刊更多论文

便秘对精神分裂症和抑郁症患者的影响：一项基于互联网的调查（考虑调查）。

背景：便秘是一种常见的胃肠道疾病，影响生活质量和工作效率。本研究评估了精神分裂症、抑郁症患者和一般人群的便秘严重程度，并检查了其对生活质量和工作效率的影响，以及患者教育和便秘管理的偏好。方法：采用基于网络的横断面调查。评估包括便秘评分系统（CSS）、简短表格8、工作效率和活动障碍问卷，以及有关便秘风险和排便习惯改变的先前解释的问题。CSS评分分为≤5分和≥6分。结果：共有800名参与者完成了调查（精神分裂症，n=200；抑郁症，n=200；一般人群，n=400）。精神分裂症和抑郁症组的CSS评分高于一般人群。多变量回归分析显示，精神分裂症和抑郁症与便秘严重程度相关。在精神分裂症和抑郁症组中，目前的症状状态和抗焦虑药的使用仍然与CSS评分独立相关。在所有组中，与CSS得分≤5的参与者相比，CSS得分≥6的参与者的心理成分总结得分较低，出勤率、整体工作效率损失和活动障碍水平较高。在每个精神分裂症和抑郁症组中，大约30%的参与者报告说，他们事先接受了有关精神药物相关便秘风险的解释，而40%的人报告说，在服用精神药物后，排便习惯发生了变化。结论：精神分裂症和抑郁症患者的便秘严重程度高于一般人群；严重程度越高，生活质量越低，工作效率越低。在这些人群中，常规筛查、便秘教育和以患者为中心的便秘管理可能是解决便秘及其相关负担的有用临床方法。试验注册：本研究已在大学医院医学信息网（UMIN000058981）注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.