Stratum Corneum Biomarkers for Differentiating Irritant and Allergic Contact Dermatitis.

IF 4.1 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2026-10-20 DOI:10.1111/cod.70268

F L de Boer, S Kezic, Ivone Jakasa, Nique M Grob, Nariman K A Metwally, Jϋrgen Claesen, Karen Ghauharali-van der Vlugt, Femke S Beers-Stet, Wouter Ouwerkerk, Thomas Rustemeyer, Henk F van der Molen

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引用次数: 0

Abstract

Background/objectives: Occupational hand dermatitis (HD) comprises irritant and allergic contact dermatitis (ICD and ACD), which share clinical features, often overlap, and may coexist with atopic dermatitis (AD), complicating diagnosis. The objective of this study is to explore whether stratum corneum (SC) biomarkers discriminate ICD from ACD.

Patients: We recruited 126 patients from the Occupational Dermato-allergology Clinics of the Amsterdam UMC.

Methods: SC samples were collected from lesional HD skin and patch test reactions to nickel, chromium, methylisothiazolinone, sodium lauryl sulfate (irritant), and control sites. Thirty-three biomarkers were analyzed. Random forest and penalized regression models were trained on the patch test dataset and validated in HD; an additional model was trained and validated in HD. Exploratory analyses evaluated discrimination among individual allergens and between AD, ICD and ACD.

Results: The patch test model showed good discrimination between ICD and ACD (mean AUC 0.85, 95% CI 0.82-0.87), driven primarily by skin barrier-related biomarkers. In HD, performance declined (mean AUC 0.51, 95% CI 0.26-0.76); sensitivity for ACD was 88%. Model trained and validated within HD achieved mean AUC of 0.60 (95% CI 0.57-0.64). Discrimination between individual allergens yielded mean AUC of 0.75 (95% CI 0.72-0.77).

Conclusion: SC biomarkers discriminated ICD from ACD good in acute patch test, but showed limited discrimination in HD, reflecting differences between acute and chronic inflammation.

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鉴别刺激性和过敏性接触性皮炎的角质层生物标志物。

背景/目的：职业性手皮炎（HD）包括刺激性接触性皮炎和过敏性接触性皮炎（ICD和ACD），它们具有共同的临床特征，经常重叠，并可能与特应性皮炎（AD）共存，使诊断复杂化。本研究的目的是探讨角质层（SC）生物标志物是否能区分ICD和ACD。患者：我们从阿姆斯特丹UMC职业皮肤过敏诊所招募了126名患者。方法：从HD病变皮肤采集SC标本，对镍、铬、甲基异噻唑啉酮、十二烷基硫酸钠（刺激物）和对照部位进行斑贴试验。分析了33种生物标志物。在patch test数据集上训练随机森林和惩罚回归模型，并在HD上进行验证；在HD中训练并验证了另一个模型。探索性分析评估了个体过敏原之间以及AD、ICD和ACD之间的区别。结果：斑贴试验模型显示ICD和ACD之间有良好的区分（平均AUC 0.85, 95% CI 0.82-0.87），主要由皮肤屏障相关的生物标志物驱动。HD患者表现下降（平均AUC 0.51, 95% CI 0.26-0.76）；ACD的敏感性为88%。在HD内训练和验证的模型的平均AUC为0.60 （95% CI 0.57-0.64）。个体过敏原之间的区分平均AUC为0.75 （95% CI 0.72-0.77）。结论：SC生物标志物在急性斑贴试验中区分ICD和ACD良好，但在HD中区分有限，反映了急性和慢性炎症的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".