Denitrogenative thiolation of benzotriazinones: facile access to ortho-thiolated benzamides.

IF 2.8 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2026-10-20 DOI:10.1039/d6ob01325b

Dasari Chaithanya, Radhakrishnan Sakthiganapathi, Jaladi Jhansi, Ramaraju Korivi, Baburaj Baskar, Subramaniyan Mannathan

引用次数: 0

Abstract

A metal-free denitrogenative thiolation of 1,2,3-benzotriazin-4(3H)-ones with thiols for the synthesis of ortho-thiolated benzamides in the presence of DBU is described. The reaction accommodates a broad range of N-aryl-substituted 1,2,3-benzotriazin-4(3H)-ones, as well as aryl and alkyl thiols, affording the desired products in moderate to high yields. The reaction is believed to proceed via a benzenediazonium intermediate. The scalability of the developed protocol was also further demonstrated.

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苯并三嗪酮的脱氮硫化：易于获得邻硫化苯酰胺。

介绍了在DBU存在下，1,2,3-苯并三嗪-4(3H)- 1与硫醇进行无金属脱氮硫化反应，以合成邻硫代苯酰胺。该反应可容纳广泛的n-芳基取代的1,2,3-苯并三嗪-4(3H)-以及芳基和烷基硫醇，以中高收率提供所需的产物。该反应被认为是通过苯二氮的中间体进行的。进一步验证了协议的可扩展性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.