Neurophysiological dynamics related to perception, action, and language in schizophrenia

IF 13.9 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2026-10-21 DOI:10.1126/sciadv.aeh5819

Hsi T. Wei, Dominic Boutet, Rukun Dou, Jessica Ahrens, Nadia Zeramdini, Alban Voppel, Fernando Gonzales-Aste, Fatme Abboud, Sylvain Baillet, Lena Palaniyappan

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Abstract

Schizophrenia disrupts both how people perceive the world and how they express and act on their thoughts, yet these symptoms are usually studied separately. Using magnetoencephalography during multisensory and motor tasks, we tested whether reduced event-related beta-band (15 to 30 hertz) modulation, a signal implicated in predictive control, provides a candidate neural marker across these domains. Compared to healthy individuals, patients showed diminished beta changes during sensory processing and movement completion, suggesting reduced flexibility in updating internal models. This neural pattern covaried with audiovisual simultaneity-judgment behavior, disorganized natural speech, and greater clinical severity. These findings suggest that distributed beta modulation may serve as a candidate cross-domain marker associated with perceptual, motor, and language disturbances in schizophrenia, motivating future studies that directly test predictive updating mechanisms.

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精神分裂症患者与感知、行动和语言相关的神经生理动力学

精神分裂症既扰乱了人们感知世界的方式，也扰乱了他们表达和行动思想的方式，但这些症状通常是分开研究的。在多感觉和运动任务中使用脑磁图，我们测试了减少事件相关的β波段（15至30赫兹）调制，一个涉及预测控制的信号，是否提供了跨这些域的候选神经标记。与健康个体相比，患者在感觉处理和运动完成过程中表现出减少的β变化，表明更新内部模型的灵活性降低。这种神经模式与视听同时判断行为、紊乱的自然语言和更严重的临床严重程度共同变化。这些发现表明，分布式β调制可能是与精神分裂症患者的知觉、运动和语言障碍相关的候选跨域标记物，这将推动未来直接测试预测更新机制的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.