Detection of female genital tract abnormalities in antenatally detected fetal unilateral renal agenesis: Original retrospective case series with review of literature

IF 2.1 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2027-01-01 Epub Date: 2026-10-07 DOI:10.1016/j.earlhumdev.2026.106692

Christina Resta, Konstantinos Malligiannis Ntalianis, Brianna Cloke, Lisa Story, Spyridon Bakalis, Pankaj Mishra, Massimo Garriboli, Srividhya Sankaran

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引用次数: 0

Abstract

Objective

In females, unilateral renal agenesis is associated with genital tract abnormalities, which can cause complications in childhood and beyond. However, its prevalence and characteristics are not consistently integrated into antenatal counselling.

Methods

An original retrospective case series study (2005–2024) at Guy's and St Thomas' Hospital identified fetuses with isolated antenatally diagnosed unilateral renal agenesis from an Astraia database, with standardized 6-week postnatal imaging.

Results

110 cases of renal agenesis were identified. Of these, fifteen cases (n = 15) were excluded due to bilateral renal agenesis and five due to additional extra-renal abnormalities (n = 5). Outcome data was unavailable for 13 cases. Of the remaining 77 cases, 44 were males and 33 females. Of female fetuses,7 were diagnosed as pelvic kidneys postnatally, with no additional abnormalities present. From the remaining 26 cases with true unilateral renal agenesis, 5 (19%) were found to have associated genital tract abnormalities, which included uterovaginal fistula (n = 2) and Herlyn-Werner-Wunderlich syndrome with a bicornuate uterus (n = 3) identified at the six-week postnatal scan.

Conclusion

Among female infants with isolated unilateral renal agenesis, 19% had associated genital tract malformations, underscoring the need for antenatal counselling and multidisciplinary approach beginning in the prenatal period.

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产前检测胎儿单侧肾发育不全中女性生殖道异常的检测：原始回顾性病例系列并复习文献。

目的：在女性中，单侧肾脏发育不全与生殖道异常有关，这可能导致儿童期及以后的并发症。然而，其流行程度和特点并没有始终纳入产前咨询。方法：Guy's and St Thomas' Hospital的一项原始回顾性病例系列研究（2005-2024）从Astraia数据库中识别出孤立的产前诊断为单侧肾脏发育不全的胎儿，并进行标准化的6周产后影像学检查。结果：确诊肾发育不全110例。其中，15例（n = 15）因双侧肾发育不全而被排除，5例因额外的肾外异常而被排除（n = 5）。13例未获得结局数据。其余77例中，男44例，女33例。在女性胎儿中，7例在出生后被诊断为盆腔肾，没有其他异常。在剩下的26例真正单侧肾发育不全的病例中，5例（19%）被发现有相关的生殖道异常，包括子宫阴道瘘（n = 2）和Herlyn-Werner-Wunderlich综合征合并双角状子宫（n = 3），在产后6周的扫描中被发现。结论：在孤立的单侧肾发育不全的女婴中，19%伴有生殖道畸形，强调了产前咨询和多学科方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.