Fibroblast growth factor in pancreatic development, homeostasis, and disease

IF 13.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2026-12-01 Epub Date: 2026-10-15 DOI:10.1016/j.cytogfr.2026.101535

Zhihua Dou, Yinling Jiang, Xin Liu, Zhilong Liu, Huisheng Liu, Haopeng Lin, Yanying Guo

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引用次数: 0

Abstract

Pancreatic development is a tightly orchestrated process driven by the concerted action of multiple signaling pathways. Fibroblast growth factors (FGFs) serve as pivotal cues across its stages: they engage FGF receptors (FGFRs) to activate downstream ERK/MAPK, PI3K–AKT, and PLCγ cascades, thereby governing pancreatic progenitor proliferation, differentiation, and functional maturation. The spatiotemporal expression of FGFs is precisely coupled to developmental milestones and intertwined with Notch, Wnt, and Hedgehog signaling in a complex regulatory network. This review systematically summarizes the molecular architecture and signal transduction of the FGF family, delineates its roles in pancreatic spatiotemporal dynamics, cell-fate determination, and maturation, examines how aberrant FGF signaling contributes to pancreatic cancer, diabetes, and pancreatitis, and reviews current FGF/FGFR-targeted therapies alongside their challenges. Future work must surmount technical bottlenecks and dissect cell-specific FGF mechanisms to underpin precision medicine for pancreatic disorders.

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成纤维细胞生长因子在胰腺发育、体内平衡和疾病中的作用。

胰腺发育是一个由多种信号通路协同作用驱动的紧密协调的过程。成纤维细胞生长因子（FGFs）在其各个阶段起着关键的作用：它们与FGF受体（fgfr）结合，激活下游ERK/MAPK、PI3K-AKT和PLCγ级联反应，从而控制胰腺祖细胞的增殖、分化和功能成熟。在一个复杂的调控网络中，FGFs的时空表达与发育里程碑精确耦合，并与Notch、Wnt和Hedgehog信号交织在一起。本文系统总结了FGF家族的分子结构和信号转导，描述了其在胰腺时空动力学、细胞命运决定和成熟中的作用，研究了异常FGF信号传导如何导致胰腺癌、糖尿病和胰腺炎，并综述了当前FGF/ fgfr靶向治疗及其面临的挑战。未来的工作必须克服技术瓶颈，解剖细胞特异性FGF机制，以支持胰腺疾病的精准医学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.