Target-controlled infusion of propofol induces rapid hypertriglyceridemia in healthy cats.

IF 1.6 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2026-10-19 DOI:26.05.0217

Francini Arboit, Luiza Tonietto Mangini, Jean Carlos Gasparotto, Leonardo Bergmann Griebeler, Júlia Odorissi Oliveira, Lisiane Saremba Vieira, Gabriel Satoru Ohashi, Vinícius da Silva Cadiñanos, Amanda Oliveira Paraguassú, Emilie Victória Oberbeck, Livia Benedeti de Souza, Gabrielle Coelho Freitas, Beatriz Perez Floriano, André Vasconcelos Soares

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Abstract

Objective: To evaluate serum triglyceride concentrations during target-controlled infusion (TCI) of propofol in healthy cats undergoing elective orchiectomy and to investigate the relationship between cumulative propofol dose and triglyceride concentrations.

Methods: 8 healthy male cats were anesthetized using propofol administered via a TCI system targeting a plasma concentration of 7 µg/mL for 45 minutes. Blood samples were collected at baseline, after premedication, immediately after induction, and at 20 and 40 minutes of infusion for determination of serum triglyceride concentrations.

Results: Serum triglycerides increased significantly following propofol administration, with elevations detectable immediately after induction. Median concentrations were 41 mg/dL (range, 31 to 75) at baseline, 32 mg/dL (range, 20 to 99) after premedication, 128 mg/dL (range, 72 to 215) immediately after induction, 132 mg/dL (range, 106 to 227) at 20 minutes of infusion, and 143 mg/dL (range, 57 to 230) at 40 minutes of infusion. During anesthesia, 75% of the animals exceeded the reference interval for triglycerides. No significant correlation was observed between propofol cumulative doses and triglyceride concentrations.

Conclusions: Target-controlled propofol infusion is associated with a rapid increase in serum triglyceride concentrations in cats even during short anesthetic procedures.

Clinical relevance: Given the use of prolonged propofol infusions in veterinary anesthesia, these findings highlight the importance of considering potential changes in serum triglyceride concentrations, particularly in patients with underlying lipid or metabolic dysfunction.

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靶控输注异丙酚诱导健康猫快速高甘油三酯血症。

目的：评价择期睾丸切除术健康猫丙泊酚靶控输注（TCI）期间血清甘油三酯浓度，探讨丙泊酚累积剂量与甘油三酯浓度的关系。方法：8只健康公猫通过TCI系统以7 μ g/mL的血浆浓度为目标，使用异丙酚麻醉45分钟。在基线、用药前、诱导后立即以及输注20和40分钟时采集血样，测定血清甘油三酯浓度。结果：异丙酚给药后血清甘油三酯显著升高，诱导后立即检测到升高。中位浓度为基线时41 mg/dL（范围31 ~ 75），用药前32 mg/dL（范围20 ~ 99），诱导后立即128 mg/dL（范围72 ~ 215），输液20分钟时132 mg/dL（范围106 ~ 227），输液40分钟时143 mg/dL（范围57 ~ 230）。在麻醉期间，75%的动物的甘油三酯超过了参考区间。在丙泊酚累积剂量和甘油三酯浓度之间没有观察到显著的相关性。结论：靶控异丙酚输注与猫血清甘油三酯浓度的快速增加有关，即使在短时间麻醉过程中也是如此。临床相关性：考虑到在兽医麻醉中使用长时间异丙酚输注，这些研究结果强调了考虑血清甘油三酯浓度潜在变化的重要性，特别是在有潜在脂质或代谢功能障碍的患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.