The Role of Membranes in Tissue Regeneration Therapy: State of the Art and Future Perspectives

IF 5.2 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2026-10-20 Epub Date: 2026-10-06 DOI:10.1021/acsomega.6c07202

Raphael Ferreira da Silva, Renata Ribeiro de Castro, Gabriela Warwar Teixeira, Paula de Souza Soares, Valéria Pereira de Sousa, Carlos Rangel Rodrigues, Flávia Almada do Carmo, Lucio Mendes Cabral

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Abstract

Membranes for tissue regeneration are an indispensable class of biomaterials in regenerative medicine, serving as selective barriers and matrices for the reconstruction of various tissues. Essential characteristics for the clinical success of a biomaterial include its biocompatibility, degradation kinetics, mechanical properties, and bioactivity, which are the focus of this review, with an emphasis on the importance of immunomodulation and the host response. The main clinical applications of this class of biomaterials are directed towards bone, cartilage, skin, and neural regeneration. In addition to evaluating the essential characteristics of these membranes, innovations such as smart, stimuli-responsive, and bioelectric membranes, as well as advances in 4D bioprinting, were also addressed. It is concluded that, despite established clinical success, the main challenges lie in overcoming material variability, vascularizing large-volume defects, and translating advanced technologies into clinical practice. Future perspectives point towards the development of personalized, smart, and bio-instructive membranes capable of actively orchestrating the regeneration process.

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膜在组织再生治疗中的作用：现状和未来展望

组织再生膜是再生医学中不可缺少的一类生物材料，是各种组织重建的选择性屏障和基质。生物材料临床成功的基本特征包括其生物相容性、降解动力学、机械性能和生物活性，这是本文的重点，强调免疫调节和宿主反应的重要性。这类生物材料的主要临床应用方向是骨、软骨、皮肤和神经再生。除了评估这些膜的基本特性外，还讨论了智能、刺激响应和生物电膜等创新，以及4D生物打印的进展。结论是，尽管取得了临床成功，但主要的挑战在于克服材料的可变性，血管大容量缺陷，以及将先进技术转化为临床实践。未来的观点指向能够主动协调再生过程的个性化、智能和生物指导膜的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.