Conformational Lability of Bispidine as a Route to New Polycyclic Compounds

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2026-10-20 DOI:10.1021/acs.joc.6c01744

Aleksei V. Medved’ko,Sergey Z. Vatsadze

引用次数: 0

Abstract

In this study, novel tricyclic compounds based on bispidine were prepared via a Michael addition–Henry domino reaction. This reaction sequence proceeds under mild conditions with high diastereoselectivity. Postsynthetic transformation pathways for the resulting nitro alcohols were demonstrated, leading to tricyclic amino alcohols of various structures.

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比斯必定作为合成新多环化合物途径的构象稳定性

本研究通过Michael加成- henry多米诺反应，制备了以比斯必定为基础的新型三环化合物。该反应序列在温和条件下进行，具有较高的非对映选择性。证明了合成后硝基醇的转化途径，导致各种结构的三环氨基醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.