Expanding the Chemical Space of Analytes in the 2G Crystalline Sponge Method: Size-Compensation Strategy for the Structural Analysis of Low-Polarity Small Molecules

IF 17.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2026-10-20 DOI:10.1002/anie.4748505

Wei He,Luc Soliman,Hiroki Takezawa,Makoto Fujita

引用次数: 0

Abstract

The accessible chemical space of second-generation crystalline sponges (2G-CSs) is extended to low-polarity small molecules via a modulator-enabled strategy. The key is the size compensation between guest and modulator to achieve a snug fit within the cage cavity.

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2G结晶海绵法扩展分析物的化学空间：用于低极性小分子结构分析的尺寸补偿策略

第二代结晶海绵（2G-CSs）的化学空间通过调制器扩展到低极性小分子。关键是来宾和调制器之间的尺寸补偿，以实现一个舒适的配合在笼腔内。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.