Recognizing Fluid Overload-Associated Large B-Cell Lymphoma on Effusion Cytology: Two Illustrative Cases.

IF 0.9 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2026-10-18 DOI:10.1002/dc.70220

Selamawit Ayele, Tesfalem Korga, Sultan Pehlivan, Shweta Gera, Mark Suhrland, Jui Choudhuri

引用次数: 0

Abstract

Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a distinct entity introduced in the 5th edition of the WHO Classification of Hematolymphoid Tumors (2022). It denotes a large B-cell lymphoma confined to one or more serous cavities as effusions, without a solid or nodal mass, in the absence of KSHV/HHV8 (and largely EBV) infection, arising in patients with fluid-overload states. It was previously reported under descriptive terms such as "HHV8-negative primary effusion lymphoma-like lymphoma." We describe two cases illustrating the WHO-HAEM5 diagnostic criteria and the diagnostic and prognostic workup of this entity.

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在积液细胞学上识别液体超载相关的大b细胞淋巴瘤：两个说明性病例。

液体超载相关的大b细胞淋巴瘤（FO-LBCL）是世卫组织第5版《淋巴类肿瘤分类》（2022年）中引入的一个独特的实体。它表示在没有KSHV/HHV8（主要是EBV）感染的情况下，一种局限于一个或多个浆液腔的大b细胞淋巴瘤，表现为积液，无实性或结节性肿块，发生于液体过载状态的患者。以前的报道用描述性术语，如“hhv8阴性原发性积液性淋巴瘤样淋巴瘤”。我们描述了两个病例，说明了WHO-HAEM5诊断标准以及该实体的诊断和预后检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.