Metal-free, photochemical on-DNA thiol-yne reaction for the stereoselective synthesis of Z-alkenyl sulfides and vinyl sulfoximines.

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2026-10-19 DOI:10.1039/d6cc05768c

Fanming Zeng, Zhirong Zheng, Yagong Wang, Ivan Hu, Xue Zhao, Feng Fan, Lijun Xue, Kexin Yang, Yun Jin Hu

引用次数: 0

Abstract

We present visible-light-driven, metal-free on-DNA thiol-yne reaction using benzil under 365 nm light to synthesize alkenyl sulfides. This mild, aqueous method preserves DNA integrity and enables direct conversion to alkenyl sulfoximines, expanding the chemical space for DNA-encoded library screening.

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无金属光化学dna上的硫醇炔反应立体选择性合成z -烯基硫化物和乙烯基亚砜胺。

我们提出了在365 nm光下，用苯乙烯在可见光驱动下合成烯基硫化物的无金属dna上的硫醇炔反应。这种温和的水相方法保留了DNA的完整性，并能够直接转化为烯基亚砜胺，扩大了DNA编码文库筛选的化学空间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.