Gastroprotective effects of chlorella derived lutein via anti-inflammatory antioxidant and acid enzyme modulation.

IF 4.5 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2026-10-06 eCollection Date: 2026-10-16 DOI:10.1016/j.isci.2026.117661

Insaf Bahrini, Maha Alazami, Muna Alamoudi

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引用次数: 0

Abstract

Induction of gastric ulcer by ethanol is associated with inflammation, oxidative stress, and impaired gastric mucosal defense. The current work was performed to determine the effect of lutein from Chlorella on ethanol-induced gastric ulcers in rats. Lutein caused significant decrease in gastric ulcer index and ulcer area (by 80.8%) and had beneficial effects on hematological and inflammatory status as seen from the 38% reduction in neutrophil, 57% reduction in myeloperoxidase activity, and 83% reduction in neutrophilic infiltration. At a dose of 200 mg/kg, lutein significantly lowered cyclooxygenase activity (50%), C-reactive protein (67%), prostaglandin E2 (55%), and nitric oxide (39%) levels. Lutein caused decrease in oxidative stress evidenced from 75% to 69% reduction in TBARS and hydrogen peroxide, and increase in the activities of superoxide dismutase, catalase, and glutathione peroxidase. Lutein exhibited dose-dependent inhibition of gastric H⁺K⁺ATPase activity and preservation of gastric mucosal integrity.

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小球藻叶黄素通过抗炎、抗氧化和酸酶调节对胃的保护作用。

乙醇诱导胃溃疡与炎症、氧化应激和胃粘膜防御受损有关。本研究旨在确定小球藻叶黄素对乙醇性大鼠胃溃疡的影响。叶黄素可显著降低胃溃疡指数和溃疡面积（80.8%），并对血液和炎症状态有有益影响，中性粒细胞降低38%，髓过氧化物酶活性降低57%，中性粒细胞浸润降低83%。在200 mg/kg剂量下，叶黄素显著降低环加氧酶活性（50%）、c反应蛋白（67%）、前列腺素E2（55%）和一氧化氮（39%）水平。叶黄素导致氧化应激降低，TBARS和过氧化氢含量降低75% ~ 69%，超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性增加。叶黄素表现出剂量依赖性的胃H+K+ atp酶活性抑制和胃粘膜完整性保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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