Commercialization of natural plant oil as a cosmetic ingredient using liquefied dimethyl ether extraction

IF 4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2027-03-01 Epub Date: 2026-10-15 DOI:10.1016/j.supflu.2026.107172

Shogo Suzuki, Shogo Torii, Kento Kunihiro, Kensuke Yotsumoto

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引用次数: 0

Abstract

We developed a manufacturing process for producing cosmetic oil ingredients by extraction with liquefied dimethyl ether (DME). Yama Sauvignon grape seeds (Vitis coignetiae/Vitis vinifera) were used as the oil source. The process yielded grape seed oil containing polyphenols. The optimum extraction conditions were an extraction temperature of 25 °C, an extraction pressure of 0.7 MPa, a residence time of 10 min, and a DME-to-seed mass ratio of 3.3 kg DME/kg grape seed. The composition and functional properties of the DME-extracted grape seed oil were compared with those of mechanically pressed oil. Compared with pressed oil, the DME-extracted oil had a higher total polyphenol concentration and stronger antioxidant and antiglycation activities. Moreover, the DME-extracted oil promoted SOD2 expression and inhibited IL-1α and IL-1β expression in human fibroblasts, and it enhanced GCLC and sXBP1 expression in human keratinocytes. These results show that liquefied DME enables the high-yield extraction of polyphenol-containing natural plant oil with desirable functional properties. The extracted grape seed oil exhibited antioxidant, antiglycation, anti-inflammatory, and cytoprotective effects, supporting its potential use as a cosmetic ingredient.

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液化二甲醚萃取天然植物油作为化妆品原料的商业化

我们开发了一种通过提取液化二甲醚（DME）来生产化妆品油成分的生产工艺。以山长相思葡萄籽（Vitis coignetiae/Vitis vinifera）为油源。这个过程产生了含有多酚的葡萄籽油。最佳提取条件为提取温度25℃，提取压力0.7 MPa，停留时间10 min，二甲醚与种子质量比为3.3 kg二甲醚/kg葡萄籽。比较了二甲醚提取的葡萄籽油与机械榨油的组成和功能特性。与压榨油相比，二甲醚提取油具有更高的总多酚浓度和更强的抗氧化和抗糖基化活性。此外，dme提取物可促进人成纤维细胞中SOD2的表达，抑制IL-1α和IL-1β的表达，增强人角质形成细胞中GCLC和sXBP1的表达。这些结果表明，液化二甲醚可以高收率地提取具有理想功能特性的含多酚的天然植物油。提取的葡萄籽油具有抗氧化、抗糖化、抗炎和细胞保护作用，支持其作为化妆品成分的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.