Midterm Outcomes of the Minos Ultralow Profile Endograft: Results from the Multicentre MINER Registry.

IF 8.5 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

European Journal of Vascular and Endovascular Surgery Pub Date : 2026-10-16 DOI:10.1016/j.ejvs.2026.10.011

Michele Antonello, Marco J Bilato, Diego Cognolato, Francesco Talarico, Roberto Silingardi, Roberto Chiappa, Stefano Bonvini, Enrico Maria Marone, Sonia Ronchey, Franco Grego, Michele Piazza, Francesco Squizzato

{"title":"Midterm Outcomes of the Minos Ultralow Profile Endograft: Results from the Multicentre MINER Registry.","authors":"Michele Antonello, Marco J Bilato, Diego Cognolato, Francesco Talarico, Roberto Silingardi, Roberto Chiappa, Stefano Bonvini, Enrico Maria Marone, Sonia Ronchey, Franco Grego, Michele Piazza, Francesco Squizzato","doi":"10.1016/j.ejvs.2026.10.011","DOIUrl":null,"url":null,"abstract":"Objective: The aim of this study was to assess midterm outcomes of the ultralow profile Minos endograft in a physician initiated registry.Methods: A non-sponsored registry collected consecutive patients treated with the Minos device in 20 Italian centres (2021 - 2025). Elective patients (the primary analysis population) were stratified by access quality (hostile vs. standard access); hostile iliac-femoral access was defined by a narrowest iliac diameter < 7 mm, iliac artery tortuosity index > 1.6, aortic bifurcation diameter < 16 mm, or severe circumferential calcification. Proximal neck features were covariates only; urgent and emergent procedures were analysed separately. Outcomes were thirty day technical success, mortality, and major adverse events (MAEs), and midterm freedom from rupture, limb occlusion, type I or III endoleak, and re-intervention.Results: Of 310 patients (mean aneurysm diameter 54.8 ± 10.0 mm), 288 (92.9%) were elective. Among these, 154 (53.5%) had a standard access and 134 (46.5%) a hostile access. The latter were more frequently women (16.4% vs. 6.0%; p = .009) and more frequently had peripheral arterial disease (31.6% vs. 16.8%; p = .006). Elective technical success was 100%, with no thirty day deaths. The thirty day MAE rate was higher with hostile access (8.2% vs. 1.3%; p = .032), mainly from access related events and blood loss > 1 000 mL (3.7% vs. 0.0%; p = .021), as was early re-intervention (3.7% vs. 0.0%; p = .021). At 3 years there were no aneurysm related deaths; freedom from limb occlusion was 97% vs. 100% (p = .025) and from type I OR III endoleak was 98% vs. 100% (p = .18) in the standard and hostile access groups, respectively.Conclusion: The Minos ultralow profile endograft was safe and effective for the treatment of elective abdominal aortic aneurysms. Peri-operative morbidity was higher when the iliac-femoral access was hostile, and limb occlusion, type I - III endoleak, and re-intervention were more evident compared with standard access anatomy. An ultralow profile platform can extend endovascular repair to unfavourable access vessels without affecting midterm device performance.","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":8.5000,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Vascular and Endovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ejvs.2026.10.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of this study was to assess midterm outcomes of the ultralow profile Minos endograft in a physician initiated registry.

Methods: A non-sponsored registry collected consecutive patients treated with the Minos device in 20 Italian centres (2021 - 2025). Elective patients (the primary analysis population) were stratified by access quality (hostile vs. standard access); hostile iliac-femoral access was defined by a narrowest iliac diameter < 7 mm, iliac artery tortuosity index > 1.6, aortic bifurcation diameter < 16 mm, or severe circumferential calcification. Proximal neck features were covariates only; urgent and emergent procedures were analysed separately. Outcomes were thirty day technical success, mortality, and major adverse events (MAEs), and midterm freedom from rupture, limb occlusion, type I or III endoleak, and re-intervention.

Results: Of 310 patients (mean aneurysm diameter 54.8 ± 10.0 mm), 288 (92.9%) were elective. Among these, 154 (53.5%) had a standard access and 134 (46.5%) a hostile access. The latter were more frequently women (16.4% vs. 6.0%; p = .009) and more frequently had peripheral arterial disease (31.6% vs. 16.8%; p = .006). Elective technical success was 100%, with no thirty day deaths. The thirty day MAE rate was higher with hostile access (8.2% vs. 1.3%; p = .032), mainly from access related events and blood loss > 1 000 mL (3.7% vs. 0.0%; p = .021), as was early re-intervention (3.7% vs. 0.0%; p = .021). At 3 years there were no aneurysm related deaths; freedom from limb occlusion was 97% vs. 100% (p = .025) and from type I OR III endoleak was 98% vs. 100% (p = .18) in the standard and hostile access groups, respectively.

Conclusion: The Minos ultralow profile endograft was safe and effective for the treatment of elective abdominal aortic aneurysms. Peri-operative morbidity was higher when the iliac-femoral access was hostile, and limb occlusion, type I - III endoleak, and re-intervention were more evident compared with standard access anatomy. An ultralow profile platform can extend endovascular repair to unfavourable access vessels without affecting midterm device performance.

查看原文本刊更多论文

Minos超低侧位内移植物的中期结果：来自多中心MINER注册的结果

目的：本研究的目的是在医生发起的注册中评估超低配置Minos内移植物的中期结果。方法：非赞助注册收集了意大利20个中心（2021 - 2025）连续使用Minos装置治疗的患者。择期患者（主要分析人群）按准入质量（敌对与标准准入）分层；不利的髂-股通道定义为最窄的髂动脉直径< 7 mm，髂动脉弯曲指数bbb1.6，主动脉分叉直径< 16 mm，或严重的周向钙化。近端颈部特征仅为协变量；分别分析了紧急程序和紧急程序。结果是30天的技术成功、死亡率和主要不良事件（MAEs），中期无破裂、肢体闭塞、I型或III型渗漏和再次干预。结果：310例患者（平均动脉瘤直径54.8±10.0 mm）中，288例（92.9%）为选择性。其中，154个（53.5%）为标准接入，134个（46.5%）为敌对接入。后者更常见的是女性（16.4%比6.0%,p = 0.009），更常见的是外周动脉疾病（31.6%比16.8%,p = 0.006）。选择性技术成功率为100%，无30天死亡病例。不良通路30天MAE率较高（8.2% vs. 1.3%, p = 0.032），主要来自通路相关事件和1 000 mL失血（3.7% vs. 0.0%, p = 0.021），早期再干预也是如此（3.7% vs. 0.0%, p = 0.021）。3年后没有动脉瘤相关死亡；在标准组和敌对通路组中，肢体闭塞的自由度分别为97%和100% (p = 0.025)， I型或III型内漏的自由度分别为98%和100% （p = 0.18）。结论：Minos超低侧位内移植物治疗选择性腹主动脉瘤安全有效。髂-股通道不通畅时围手术期发病率较高，与标准通道解剖相比，肢体闭塞、I - III型内漏和再干预更为明显。超低轮廓平台可以将血管内修复扩展到不利的通路血管，而不会影响设备的中期性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Vascular and Endovascular Surgery 医学-外科

CiteScore

6.80

自引率

15.80%

发文量

471

审稿时长

66 days

期刊介绍： The European Journal of Vascular and Endovascular Surgery is aimed primarily at vascular surgeons dealing with patients with arterial, venous and lymphatic diseases. Contributions are included on the diagnosis, investigation and management of these vascular disorders. Papers that consider the technical aspects of vascular surgery are encouraged, and the journal includes invited state-of-the-art articles. Reflecting the increasing importance of endovascular techniques in the management of vascular diseases and the value of closer collaboration between the vascular surgeon and the vascular radiologist, the journal has now extended its scope to encompass the growing number of contributions from this exciting field. Articles describing endovascular method and their critical evaluation are included, as well as reports on the emerging technology associated with this field.