Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes (Adv. Healthcare Mater. 38/2026)

IF 11 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI:10.1002/adhm.71678

Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng

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引用次数: 0

Abstract

Photodynamic Immunomodulation

The cover illustrates a self-assembled porphyrin polymer (PTCPP) activated by near-infrared light to eradicate drug-resistant bacterial biofilms on cardiac implants. Simultaneously, PTCPP dynamically regulates macrophage polarization through immunometabolic modulation, promoting inflammation resolution and tissue regeneration. This dual antibacterial-immunomodulatory strategy provides a promising approach for preventing diabetic cardiac implant-associated infections. More details can be found in the Research Article by Jing Zhu, Xiaochen Wang, Sheng Ye, Cheng Cheng, and co-workers (DOI: 10.1002/adhm.71482).

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具有优越电荷转移的共轭卟啉聚合物在光动力免疫调节预防糖尿病CIED感染中的应用[j] .中华医学杂志。38/2026。

该封面展示了一种由近红外光激活的自组装卟啉聚合物（PTCPP），以消除心脏植入物上的耐药细菌生物膜。同时，PTCPP通过免疫代谢调节动态调节巨噬细胞极化，促进炎症消退和组织再生。这种双重抗菌-免疫调节策略为预防糖尿病性心脏植入物相关感染提供了一种有前途的方法。更多细节可以在朱静、王晓晨、叶胜、程程及其同事的研究文章中找到（DOI: 10.1002/ admm .71482）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.