A Direct Additive-Free Route to Oxindole–Nitrones From α-Diazoacetamides and Nitrosoarenes

IF 2.3 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-10-15 DOI:10.1002/ajoc.70564

Mohd Abdulla, Indrajith K. Biju, Ruchir Kant, Kishor Mohanan

引用次数: 0

Abstract

A straightforward synthesis of (E)-oxindole–nitrones has been developed through the intramolecular cyclization of an in situ-generated acetamide–nitrone intermediate from the reaction of α-diazoacetamides with nitrosoarenes. The transformation proceeds under additive-free conditions in acetonitrile, exhibits a broad substrate scope, and furnishes the desired products in moderate to excellent yields.

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α-重氮乙酰胺和亚硝基芳烃直接无添加剂合成氧吲哚-硝基酮的研究

通过α-重氮乙酰胺与亚硝基芳烃的原位生成的乙酰胺-硝基中间体的分子内环化，直接合成了(E)-氧吲哚-硝基酮。转化在乙腈中无添加剂条件下进行，表现出广泛的底物范围，并以中等至优异的收率提供所需的产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.