Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report

IF 0.5 Q4 Medicine

IJU Case Reports Pub Date : 2026-10-15 DOI:10.1002/iju5.70282

Yuki Hashimoto, Kosuke Shimizu, Masayuki Uegaki, Fumihiko Kono, Toru Yoshida

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Abstract

Introduction

Yolk sac tumors are malignant germ cell tumors that typically arise in the gonads. Although extragonadal cases have been reported, primary involvement of the urinary tract is extremely rare.

Case Presentation

A 67-year-old man presented with gross hematuria. Cystoscopy and contrast-enhanced computed tomography revealed a 6-cm bladder mass. Transurethral resection of the bladder tumor was performed. Histopathological and immunohistochemical findings (alpha-fetoprotein, glypican-3, and Sal-like protein 4 positivity) were consistent with a yolk sac tumor without a urothelial carcinoma component. Additional examinations revealed no primary lesions elsewhere, leading to the diagnosis of a primary bladder yolk sac tumor. The patient received four cycles of etoposide and cisplatin chemotherapy and has remained recurrence-free for 2 years.

Conclusions

Patients with primary bladder yolk sac tumors, although rare, may achieve favorable outcomes with combined surgical resection and chemotherapy.

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原发性纯卵黄囊膀胱肿瘤1例报告

卵黄囊肿瘤是一种恶性生殖细胞肿瘤，通常发生在生殖腺。虽然有肛外病例的报道，但原发累及泌尿道的病例极为罕见。一名67岁男性，主要表现为肉眼血尿。膀胱镜检查和增强计算机断层扫描显示一个6厘米的膀胱肿块。经尿道膀胱肿瘤切除术。组织病理学和免疫组织化学检查结果（甲胎蛋白、glypican-3和sal样蛋白4阳性）与卵黄囊肿瘤一致，没有尿路上皮癌成分。其他检查未发现原发性病变，因此诊断为原发性膀胱卵黄囊肿瘤。患者接受依托泊苷和顺铂化疗4个周期，2年无复发。结论原发性膀胱卵黄囊肿瘤虽罕见，但经手术切除联合化疗可获得良好的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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