ATP-citrate lyase regulates nuclear acetyl-coA levels to promote histone acetylation and is essential to maintain human trophoblast stemness and mouse placental and fetal growth

IF 3.1 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI:10.1016/j.placenta.2026.08.058

Irving Aye, Giulia Avellino, Stephanie Rogers, Delia Hawkes, Eleanor Ward, Jacqueline Guettler, Dafina Angelova, Gordon Smith, Stephen Charnock-Jones

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atp -柠檬酸裂解酶调节核乙酰辅酶a水平，促进组蛋白乙酰化，对维持人滋养细胞的干性和小鼠胎盘和胎儿的生长至关重要

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.