Reconfiguration of the Cognitive Control Network Induced by Cerebral and Cerebro–Cerebellar Transcranial Direct Current Stimulation

IF 4.5 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Annals of the New York Academy of Sciences Pub Date : 2026-10-16 DOI:10.1111/nyas.70420

Tingting Guo, Qianwen Chang, Xuedi Liu, Qinpu Dang, Jingyu Chen, Si Chen, Taomei Guo

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Abstract

Cognitive control can be modulated by noninvasive brain stimulation, but it remains unclear how different stimulation protocols are associated with task-related network organization. To characterize behavioral and brain-network profiles, we recorded brain activity and behavioral performance while participants completed a cognitive control task during functional magnetic resonance imaging. Profiles were compared across a pre-stimulation session and two sessions following high-definition transcranial direct current stimulation (HD-tDCS): single-site stimulation of the presupplementary motor area/dorsal anterior cingulate cortex (preSMA/dACC) and dual-site stimulation of the preSMA/dACC plus the left posterolateral cerebellum. Drift-diffusion modeling showed reliable switching costs across sessions, with smaller latent costs in the dual-site than in the single-site session. Effective-connectivity analyses indicated threshold-sensitive reductions in retained cerebro–cerebellar and right prefrontal edges in the dual-site session. Model-based graph analyses indicated protocol-dependent differences in estimated network topology, including higher small-worldness in the single-site session and session-specific associations between graph metrics and latent behavioral costs. Together, these findings suggest that single-site medial-frontal and dual-site cerebro–cerebellar HD-tDCS were associated with distinct cognitive-control profiles at both behavioral and modeled network levels. Rather than reflecting a uniform enhancement of connectivity, the dual-site protocol appeared to engage a different network configuration supporting cognitive control.

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经颅直流电刺激脑及脑-小脑认知控制网络的重构

认知控制可以通过非侵入性脑刺激来调节，但目前尚不清楚不同的刺激方案如何与任务相关的网络组织相关联。为了描述行为和脑网络特征，我们在功能磁共振成像期间记录了参与者完成认知控制任务时的大脑活动和行为表现。在高清晰度经颅直流电刺激（HD - tDCS）后的两个阶段比较了刺激前和高清晰度经颅直流电刺激（HD - tDCS）的特征：前辅助运动区/背前扣带皮层（preSMA/dACC）的单部位刺激和preSMA/dACC加左小脑后外侧的双部位刺激。漂移-扩散模型显示了可靠的会话切换成本，双站点会话的潜在成本比单站点会话的潜在成本更小。有效连通性分析表明，在双位点会话中，保留的脑小脑和右前额叶边缘的阈值敏感性降低。基于模型的图分析表明，估计网络拓扑存在协议依赖差异，包括单站点会话中较高的小世界性，以及图度量与潜在行为成本之间特定会话的关联。综上所述，这些发现表明单位点内侧额叶和双位点脑小脑HD - tDCS在行为和模型网络水平上与不同的认知控制特征相关。而不是反映一个统一的连接增强，双站点协议似乎涉及一个不同的网络配置支持认知控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of the New York Academy of Sciences 综合性期刊-综合性期刊

CiteScore

11.00

自引率

1.90%

发文量

193

审稿时长

2-4 weeks

期刊介绍： Published on behalf of the New York Academy of Sciences, Annals of the New York Academy of Sciences provides multidisciplinary perspectives on research of current scientific interest with far-reaching implications for the wider scientific community and society at large. Each special issue assembles the best thinking of key contributors to a field of investigation at a time when emerging developments offer the promise of new insight. Individually themed, Annals special issues stimulate new ways to think about science by providing a neutral forum for discourse—within and across many institutions and fields.