Serum Tau and α-Synuclein in Children With Attention-Deficit/Hyperactivity Disorder: Cross-Sectional Associations With Methylphenidate Treatment

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Human Psychopharmacology: Clinical and Experimental Pub Date : 2026-10-16 DOI:10.1002/hup.70068

Deniz Doğan, Elvan İşeri, Aybeniz Civan Kahve, Samet Can Demirci, Dicle Büyüktaşkın, Ahmet Özaslan, Taner Çin, Esra Kara Aşkın, Önder Aydemir, Özlem Gülbahar, Gizem Yaz Aydın, Tuba Saadet Deveci Bulut, Süreyya Barun

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引用次数: 0

Abstract

Objective

To compare serum total tau and α-synuclein among controls, drug-naïve children with attention-deficit/hyperactivity disorder (ADHD) and children with ADHD receiving methylphenidate.

Methods

Original ELISA spreadsheets provided 26 controls, 29 evaluable drug-naïve participants and 32 methylphenidate-treated participants. Boundary-coded results (> 500 pg/mL for tau; < 938 pg/mL for α-synuclein) were assigned the recorded boundary for rank-based analyses. Groups were compared using Kruskal–Wallis tests and Dunn–Bonferroni contrasts; within-group associations used Spearman correlations.

Results

α-Synuclein differed among groups (H = 49.859, p < 0.001, ε² = 0.570), with all pairwise contrasts significant. Tau also differed (H = 10.492, p = 0.005, ε² = 0.101); drug-naïve ADHD had lower tau than controls, whereas the treated group differed from neither comparator after correction. The α-synuclein–tau correlation remained significant after false-discovery-rate adjustment only in drug-naïve ADHD (ρ = 0.443, adjusted p = 0.048).

Conclusions

Serum α-synuclein and total tau showed distinct cross-sectional group patterns. These associations do not establish methylphenidate effects and require prospective confirmation.

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design