Diet quality and prognosis in patients with non-muscle invasive bladder cancer: the Be-Well Study.

IF 2.3 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology Pub Date : 2026-10-15 DOI:10.1016/j.urology.2026.10.010

Isaac J Ergas, Alexa Zimbalist, Reina Haque, Valerie S Lee, Janise M Roh, Kimberly L Cannavale, Zinian Wang, Ronald K Loo, David S Aaronson, Charles P Quesenberry, Lawrence H Kushi, Li Tang, Marilyn L Kwan

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引用次数: 0

Abstract

Objective: To evaluate whether diet quality around the time of diagnosis is associated with risks of recurrence and progression among individuals with non-muscle invasive bladder cancer (NMIBC).

Methods: We conducted a prospective cohort study within a large integrated healthcare system. A total of 1,143 adults with newly diagnosed primary NMIBC were enrolled between 2015 and 2019. Dietary intake 12 months prior was assessed using food frequency questionnaires. Four diet quality indices were calculated-American Cancer Society guidelines, alternative Healthy Eating Index, 2020 Healthy Eating Index (HEI), Healthy Plant-Based Dietary Index-and then categorized into quartiles (Q). Recurrence and progression were determined through chart review approximately 2 years after diagnosis. Kaplan-Meier curves visualized recurrence-free survival, and multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) were estimated, with analyses stratified by treatment.

Results: Among the 1,143 participants, 325 (28.4%) experienced recurrence and 52 (4.5%) had progression over 2 years. Higher diet quality was associated with lower recurrence risk for the HEI (Q4 vs Q1: HR=0.72; 95% CI, 0.52-0.99). In stratified analyses, lower recurrence risk was more pronounced among patients who did not receive intravesical chemotherapy mitomycin C (Q4 vs Q1 HR=0.60; 95% CI, 0.41-0.90). No associations were observed for progression.

Conclusions: Of the four diet quality indices, the highest HEI quartile was associated with lower NMIBC recurrence risk, particularly among patients not treated with mitomycin C. Diet quality may be an important modifiable risk factor in NMIBC survivorship.

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非肌性浸润性膀胱癌患者的饮食质量与预后：Be-Well研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

9.50%

发文量

716

审稿时长

59 days

期刊介绍： Urology is a monthly, peer–reviewed journal primarily for urologists, residents, interns, nephrologists, and other specialists interested in urology The mission of Urology®, the "Gold Journal," is to provide practical, timely, and relevant clinical and basic science information to physicians and researchers practicing the art of urology worldwide. Urology® publishes original articles relating to adult and pediatric clinical urology as well as to clinical and basic science research. Topics in Urology® include pediatrics, surgical oncology, radiology, pathology, erectile dysfunction, infertility, incontinence, transplantation, endourology, andrology, female urology, reconstructive surgery, and medical oncology, as well as relevant basic science issues. Special features include rapid communication of important timely issues, surgeon''s workshops, interesting case reports, surgical techniques, clinical and basic science review articles, guest editorials, letters to the editor, book reviews, and historical articles in urology.