{"title":"Engineering root development with high precision.","authors":"Roza D Bilas, Sarah Guiziou","doi":"10.1111/nph.71583","DOIUrl":null,"url":null,"abstract":"<p><p>Root development is controlled by dynamic interactions between gene regulation, hormonal signalling, developmental history and environmental inputs, creating multiple layers of control that can be harnessed for engineering. Recent advances in single-cell technologies, spatial transcriptomics and synthetic biology are beginning to resolve root development at the cellular level and enable increasingly precise manipulation of developmental programmes. Here, we discuss how lineage tracing, genetic recording of developmental history, cell-type-specific engineering and programmable genetic circuits can be integrated to understand and control root architecture. We highlight emerging strategies for engineering adaptive and context-dependent developmental behaviours, including history-dependent and reversible response programmes and rewired root-environment interactions. Together, these approaches establish a foundation for programmable and adaptive root system engineering in plants.</p>","PeriodicalId":48887,"journal":{"name":"New Phytologist","volume":" ","pages":""},"PeriodicalIF":8.1000,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Phytologist","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1111/nph.71583","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
Root development is controlled by dynamic interactions between gene regulation, hormonal signalling, developmental history and environmental inputs, creating multiple layers of control that can be harnessed for engineering. Recent advances in single-cell technologies, spatial transcriptomics and synthetic biology are beginning to resolve root development at the cellular level and enable increasingly precise manipulation of developmental programmes. Here, we discuss how lineage tracing, genetic recording of developmental history, cell-type-specific engineering and programmable genetic circuits can be integrated to understand and control root architecture. We highlight emerging strategies for engineering adaptive and context-dependent developmental behaviours, including history-dependent and reversible response programmes and rewired root-environment interactions. Together, these approaches establish a foundation for programmable and adaptive root system engineering in plants.
期刊介绍：
New Phytologist is a leading publication that showcases exceptional and groundbreaking research in plant science and its practical applications. With a focus on five distinct sections - Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology - the journal covers a wide array of topics ranging from cellular processes to the impact of global environmental changes. We encourage the use of interdisciplinary approaches, and our content is structured to reflect this. Our journal acknowledges the diverse techniques employed in plant science, including molecular and cell biology, functional genomics, modeling, and system-based approaches, across various subfields.
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