5-HT_2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.

IF 20.3 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2026-10-15 DOI:10.1038/s41593-026-02490-y

Jacob J Baker, Emily Kogan, Shaorong Ma, Ju Lu, Yi Zuo

引用次数: 0

Abstract

It is unclear how serotonin 2A receptors (5-HT_2ARs) in cortical layer 5 pyramidal neurons differentially contribute to psilocybin-induced hallucinations versus neuroplasticity. Here we show that psilocybin promotes synapse formation and maturation while accelerating the elimination of pre-existing synapses. Cell type-specific manipulation further demonstrated that 5-HT_2AR signaling in cortical layer 5 pyramidal neurons is necessary and sufficient for psilocybin-induced synaptic remodeling but dispensable for the head-twitch response, a rodent proxy of hallucination.

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第5层锥体神经元中的5- ht2a受体介导裸盖菇素的神经可塑性作用，但不介导致幻作用。

目前尚不清楚皮层第5层锥体神经元中的5-羟色胺2A受体（5- ht2ars）在裸盖菇素诱导的幻觉和神经可塑性中的差异。在这里，我们表明裸盖菇素促进突触的形成和成熟，同时加速消除预先存在的突触。细胞类型特异性操作进一步证明，皮质第5层锥体神经元中的5- ht2ar信号对于裸盖菇素诱导的突触重塑是必要和充分的，但对于头抽搐反应（一种啮齿动物的幻觉代理）是必不可少的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.

5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.

Abstract

5-HT_2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.