{"title":"Nucleic Acid Therapeutics in an Age of Artificial Intelligence.","authors":"David R Corey","doi":"10.1177/21593337261496161","DOIUrl":null,"url":null,"abstract":"<p><p>Artificial intelligence (AI) is transforming how scientific hypotheses are formulated, tested, and applied. Nucleic acid therapeutics can benefit from emerging opportunities but will also face new challenges. AI lowers the barrier to hypothesis generation, increasing the emphasis on critical evaluation, rigorous experimental testing, and expert judgement. The goal of this perspective is to begin that discussion, with an emphasis on basic and applied research at the interface of nucleic acid science and medicine.</p>","PeriodicalId":19412,"journal":{"name":"Nucleic acid therapeutics","volume":" ","pages":"269-274"},"PeriodicalIF":4.5000,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acid therapeutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/21593337261496161","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/10/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Artificial intelligence (AI) is transforming how scientific hypotheses are formulated, tested, and applied. Nucleic acid therapeutics can benefit from emerging opportunities but will also face new challenges. AI lowers the barrier to hypothesis generation, increasing the emphasis on critical evaluation, rigorous experimental testing, and expert judgement. The goal of this perspective is to begin that discussion, with an emphasis on basic and applied research at the interface of nucleic acid science and medicine.
期刊介绍:
Nucleic Acid Therapeutics is the leading journal in its field focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. The Journal examines many new approaches for using nucleic acids as therapeutic agents or in modifying nucleic acids for therapeutic purposes including: oligonucleotides, gene modification, aptamers, RNA nanoparticles, and ribozymes.