Epigenetic factors in eating disorders: Clinical correlates and diagnostic specificity.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2026-01-01 DOI:10.1016/B978-0-443-19043-8.00011-6

Linda Booij, Édith Breton, Lea Thaler, Howard Steiger

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Abstract

In this chapter, we discuss epigenetic factors in eating disorders. Following a brief introduction to eating disorders, we review research on how different environmental factors - gestational, psychosocial, nutritional, and metabolic - could impact the epigenome and eating-disorder development. We review the literature providing evidence for DNA methylation alterations in eating disorders in genes regulating mental health, metabolism, and immune function. We also review researchthat has suggested that DNA methylation patterns in anorexia nervosa may be reversible upon remission. Although most epigenetic research in eating disorders focuses on anorexia nervosa, there is some evidence of epigenetic overlap between eating disorders, on the one hand, and other psychiatric metabolic and autoimmune disorders, on the other. Shared epigenetic alterations may contribute to comorbidity patterns. Overall, results of epigenetic genome-wide research in eating disorders mirror the findings from genome-wide association studies, and underscore the importance of incorporating metabolic, psychiatric, and immune components in etiologic models of eating disorders. We conclude our chapter with an integrated etiologic epigenetic model, provide avenues for future research, and discuss the clinical potentials, for eating disorders, of epigenetic markers.

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饮食失调的表观遗传因素：临床相关性和诊断特异性。

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.