Genome-Wide Association Study of Body Measurement Traits at Birth in Cattle.

IF 3.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2026-10-06 DOI:10.3390/ani16193133

Xinlu Wang, Weiguo Ju, Xiaoming Ma, Min Chu, Yongfu La, Xian Guo, Ping Yan, Bo Yang, Chunnian Liang

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引用次数: 0

Abstract

Hexi cattle are an indigenous beef population developed through multigenerational crossing of Simmental and Mongolian cattle, exhibiting exceptional adaptability to arid and semi-arid environments alongside robust growth performance. To investigate the genetic architecture underlying early growth traits, we conducted a GWAS for body weight (BW), withers height (WH), body length (BL), and heart girth (HG) in a cohort of 264 Hexi cattle (125 males, 139 females). Phenotypic analyses showed that male calves had significantly higher values for all traits relative to female calves (p < 0.05), confirming the presence of sexual dimorphism. The genomic inflation factors (λ = 0.997-1.016) indicated that population structure was effectively controlled. In total, 11 functional candidate genes were identified under the genome-wide significant threshold of p < 1.0 × 10^-6. Specifically, SLC44A1 associated with BW; PTGS2, POP1, and ERC2 with WH; TIAM1, PROK1, SMOC2, and RFFL with BL; and C3orf80, PROKR1, and FBXO32 with HG. These results not only advance our understanding of the genetic regulation of early development in Hexi cattle but also establish a foundation for implementing marker-assisted and genomic selection in this population.

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牛出生体测量性状的全基因组关联研究。

河西牛是通过西门塔尔牛和蒙古牛的多代杂交而发展起来的本土肉牛种群，对干旱和半干旱环境具有特殊的适应性，生长性能强劲。为了研究早期生长性状的遗传结构，我们对264头河西牛（雄性125头，雌性139头）进行了体重（BW）、肩高（WH）、体长（BL）和心围（HG）的遗传分析。表型分析表明，雄性犊牛的各项性状值均显著高于雌性犊牛（p < 0.05），证实了雌雄二态现象的存在。基因组膨胀因子（λ = 0.997 ~ 1.016）表明种群结构得到有效控制。在p < 1.0 × 10-6的全基因组显著阈值下，共鉴定出11个功能性候选基因。具体来说，SLC44A1与BW相关；PTGS2、POP1和ERC2与WH；TIAM1、PROK1、SMOC2、RFFL与BL；这些结果不仅促进了我们对河西牛早期发育的遗传调控的认识，而且为在该群体中实施标记辅助选择和基因组选择奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).