Association between childbirth history and multiple health outcomes.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2026-07-25 eCollection Date: 2026-01-01 DOI:10.5114/aoms/224184

Lizhong Yin, Huiwen Hu, Xuting Shi, Jiali Xiong

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引用次数: 0

Abstract

Introduction: The aim of the study was to investigate the association between childbirth experience and multiple health outcomes, and to discuss the role of blood lipids.

Material and methods: The cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020. Childbirth history (e.g., parity or number of live births) was obtained from questionnaire data. Blood lipid parameters included triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Remnant cholesterol (RC) was calculated based on standard lipid equations.

Results: A total of 3889 participants were included in this study. Compared with women without childbirth history, the prevalence of several conditions was significantly higher among women with childbirth history, including high blood pressure (40.77% vs. 19.57%, p < 0.001), diabetes (13.15% vs. 5.86%, p < 0.001), heart disease (7.75% vs. 1.69%, p < 0.001) and arthritis (35.22% vs. 17.57%, p < 0.001). Individuals with two diseases were the most common (29.1%), and overweight-high blood pressure-arthritis was the most important comorbidity pattern. After multivariable adjustment, childbirth history was associated with higher odds of seven medical conditions (heart disease, cancer, kidney stones, arthritis, thyroid problem, diabetes, and high blood pressure). Odds ratios (OR) ranged from 1.57 to 3.54 and 95% confidence intervals (CIs) from 1.15 to 6.97 (p < 0.0001), depending on the outcome. In addition, the level of RC was significantly higher among women with these conditions (p < 0.001). A nonlinear (L-shaped) association between RC and several outcomes, including heart disease, arthritis, cancer, diabetes, and high blood pressure, was observed. Mediation analysis suggested that blood RC explained 8.2%, 10.6%, 6.84%, 17.7%, and 12.5% of the association between childbirth history and these outcomes.

Conclusions: Childbirth history was associated with multiple health outcomes in women, and RC may serve as a potential biomarker and partial mediator in these associations.

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分娩史与多种健康结果之间的关系

前言：本研究的目的是调查分娩经历与多种健康结果之间的关系，并讨论血脂的作用。材料和方法：横断面研究使用了2007年至2020年国家健康和营养检查调查（NHANES）的数据。分娩史（如胎次或活产数）从问卷数据中获得。血脂参数包括甘油三酯、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。根据标准脂质方程计算残余胆固醇（RC）。结果：本研究共纳入3889名受试者。与无分娩史的女性相比，有分娩史的女性有高血压（40.77% vs. 19.57%, p < 0.001）、糖尿病（13.15% vs. 5.86%, p < 0.001）、心脏病（7.75% vs. 1.69%, p < 0.001）和关节炎（35.22% vs. 17.57%, p < 0.001）等疾病的患病率明显高于无分娩史的女性。患有两种疾病的个体最为常见（29.1%），超重-高血压-关节炎是最重要的合并症。在多变量调整后，分娩史与7种疾病（心脏病、癌症、肾结石、关节炎、甲状腺问题、糖尿病和高血压）的较高几率相关。根据结果，比值比（OR）为1.57 ~ 3.54,95%置信区间（ci）为1.15 ~ 6.97 （p < 0.0001）。此外，患有这些疾病的女性的RC水平明显更高（p < 0.001）。研究发现，RC与心脏病、关节炎、癌症、糖尿病和高血压等多种预后结果呈非线性（l型）关联。中介分析表明，血液RC解释了8.2%、10.6%、6.84%、17.7%和12.5%的分娩史与这些结果的相关性。结论：分娩史与妇女的多种健康结局相关，而RC可能在这些关联中作为潜在的生物标志物和部分中介。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

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