HDL-related inflammatory biomarkers are associated with sleep disorders: Evidence from a cross-sectional NHANES study.

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Clinical and Experimental Medicine Pub Date : 2026-10-15 DOI:10.17219/acem/214708

Lutong Gan, Yixian Cai, Xian Shi, Simeng Feng, Tuzhi Wang, Zerui You, Jiyang Pan

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引用次数: 0

Abstract

Background: Sleep disorders are common and heterogeneous conditions associated with systemic inflammation. They can impair quality of life and increase disease burden. Currently, studies investigating the association between sleep disorders and high-density lipoprotein (HDL)-related inflammatory biomarkers are lacking.

Objectives: This study aimed to explore the associations between HDL-related inflammatory biomarkers and sleep disorders.

Material and methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES; 2005-2014). Multivariable logistic regression models were applied to explore the associations between HDL-related inflammatory biomarkers, including platelet-to-HDL ratio (PHR), lymphocyte-to-HDL ratio (LHR), neutrophil-to-HDL ratio (NHR), and monocyte-to-HDL ratio (MHR), and the prevalence of sleep disorders and sleep duration. Subgroup analyses were conducted to investigate potential interactions. In addition, the nonlinear relationship between these inflammatory biomarkers and the likelihood of sleep disorders was assessed using restricted cubic spline (RCS) models. Finally, the robustness of the observed associations was examined through sensitivity analyses.

Results: A total of 23,045 individuals were included. In the fully adjusted models, higher MHR (odds ratio (OR) = 1.33; 95% confidence interval (95% CI): 1.11-1.60), NHR (OR = 1.25; 95% CI: 1.04-1.49), LHR (OR = 1.24; 95% CI: 1.05-1.48), and PHR (OR = 1.18; 95% CI: 1.00-1.39) were positively associated with an increased prevalence of sleep disorders. The RCS analysis revealed linear relationships between these inflammatory biomarkers and the likelihood of sleep disorders (all p for nonlinearity >0.05). Subgroup analyses indicated that sex and marital status significantly interacted with all 4 indices (all p for interaction <0.05). Compared with individuals with the recommended sleep duration (7-9 h/day), those with short (<7 h/day) and long (>9 h/day) sleep durations had elevated NHR levels.

Conclusions: This study revealed a linear association between HDL-related inflammatory biomarkers and sleep disorders. Moreover, sex and marital status modified the associations of all 4 indices with sleep disorders. In addition, these inflammatory biomarkers were associated with sleep duration.

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高密度脂蛋白相关炎症生物标志物与睡眠障碍相关：来自横断面NHANES研究的证据

背景：睡眠障碍是与全身性炎症相关的常见且异质性的疾病。它们会损害生活质量，增加疾病负担。目前，关于睡眠障碍与高密度脂蛋白（HDL）相关炎症生物标志物之间关系的研究尚缺乏。目的：本研究旨在探讨高密度脂蛋白相关炎症生物标志物与睡眠障碍之间的关系。材料和方法：本研究使用的数据来自国家健康和营养检查调查（NHANES; 2005-2014）。应用多变量logistic回归模型探讨hdl相关炎症生物标志物（包括血小板-高密度脂蛋白比率（PHR）、淋巴细胞-高密度脂蛋白比率（LHR）、中性粒细胞-高密度脂蛋白比率（NHR）和单核细胞-高密度脂蛋白比率（MHR））与睡眠障碍患病率和睡眠持续时间之间的关系。进行亚组分析以调查潜在的相互作用。此外，使用限制性三次样条（RCS）模型评估了这些炎症生物标志物与睡眠障碍可能性之间的非线性关系。最后，通过敏感性分析检验观察到的关联的稳健性。结果：共纳入受试者23,045人。在完全调整的模型中，较高的MHR(比值比(OR) = 1.33；95%可信区间（95% CI）： 1.11-1.60)、NHR （OR = 1.25; 95% CI: 1.04-1.49）、LHR （OR = 1.24; 95% CI: 1.05-1.48）和PHR （OR = 1.18; 95% CI: 1.00-1.39）与睡眠障碍患病率增加呈正相关。RCS分析显示，这些炎症生物标志物与睡眠障碍的可能性之间存在线性关系（非线性均为p < 0.05）。亚组分析表明，性别和婚姻状况与所有4项指标都有显著的相互作用（相互作用为9小时/天），睡眠时间增加了NHR水平。结论：本研究揭示了高密度脂蛋白相关炎症生物标志物与睡眠障碍之间的线性关联。此外，性别和婚姻状况改变了所有4项指标与睡眠障碍的相关性。此外，这些炎症生物标志物与睡眠时间有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

3.70

自引率

4.80%

发文量

153

审稿时长

6-12 weeks

期刊介绍： Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.