Self-assembled floxuridine prodrug nanovesicles for synergistic drug delivery and gene silencing.

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2026-10-16 DOI:10.1039/d6cc05604k

Rohith Pavan Parvathaneni, Nithiyanandan Krishnan, Hamidreza Mokhtari, Oommen P Oommen, Oommen P Varghese

引用次数: 0

Abstract

Floxosomes are self-assembled prodrug nanovesicles that exploit nucleobase molecular recognition to co-deliver floxuridine and short interfering RNA for synergistic cancer therapy. This esterase-responsive nanoplatform shows potent cytotoxicity (IC₅₀ = 3 µM) and in tandem STAT3 mRNA knockdown in human osteosarcoma cells, supporting its potential as a dual-modality nanomedicine.

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自组装氟尿定前药纳米囊泡协同给药和基因沉默。

柔体是一种自组装的药物前纳米囊泡，利用核碱基分子识别共同递送氟尿定和短干扰RNA，用于协同癌症治疗。这种酯酶反应的纳米平台在人骨肉瘤细胞中显示出强大的细胞毒性（IC50 = 3µM）和STAT3 mRNA的串联敲除，支持其作为双模纳米药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.