Cerium-based metal-organic framework linked chitosan with the aid of dialdehyde carboxymethyl cellulose as a biocompatible spacer: A new porous carrier for pH-sensitive daunorubicin delivery

IF 5.6 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2026-10-16 DOI:10.1007/s10924-026-04013-z

Malihe Pooresmaeil, Hassan Namazi

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引用次数: 0

Abstract

Considering the importance of controlled drug delivery in cancer therapy, this work aimed to design and prepare a new drug delivery system through the binding of chitosan (CS) to the cerium-based metal-organic framework (MOF(Ce)) with dialdehyde carboxymethyl cellulose (DCMC) (product denoted as MOF(Ce)-DCMC-CS) for study as a daunorubicin (DNR) carrier. The survey of published papers showed a lack of research regarding the MOF(Ce)-DCMC-CS preparation for use in controlled DNR delivery, supporting the novelty from the type of components and application viewpoints. The product was characterized using several physicochemical characterization techniques. The findings of the EDX-map analysis displayed the good distribution of the MOF(Ce) in the MOF(Ce)-DCMC-CS structure. Furthermore, the porous structure of the system, with a total pore volume of 0.061097 cm³/g and a mean pore diameter of 7.1189 nm, was verified by BET. DNR loading capacity and entrapment efficiency on MOF(Ce)-DCMC-CS were determined to be about 11.33% and 56.66%, respectively. Encouragingly, 67.59% of loaded DNR was released at pH 5.0 through the Higuchi kinetic model, while the DNR release percentage at pH 6.8 and pH 7.4 was 44.69% and 36.71% within 72 h. In vitro antibacterial studies specified the minimum inhibitory concentration (MIC) of 400 and 800 µg/mL toward Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. The outcome of the MTT test showed that the MOF(Ce)-DCMC-CS has good cytocompatibility, but it can more efficiently kill the MDA-MB 231 cells after DNR loading, with an IC50 of 17.87 µg/mL. Ultimately, the results suggest that the developed MOF(Ce)-DCMC-CS has the potential to be proposed as a smart drug carrier in cancer treatment.

Graphical Abstract

查看原文本刊更多论文

铈基金属-有机骨架连接壳聚糖与双醛羧甲基纤维素作为生物相容性间隔剂：一种新的ph敏感柔红霉素多孔载体

考虑到控制药物递送在癌症治疗中的重要性，本工作旨在设计和制备一种新的药物递送系统，通过壳聚糖（CS）结合铈基金属有机骨架（MOF(Ce)）和双醛羧甲基纤维素（DCMC）（产物标记为MOF(Ce)-DCMC-CS）作为柔红霉素（DNR）载体进行研究。对已发表论文的调查显示，缺乏关于MOF(Ce)-DCMC-CS制备用于可控DNR递送的研究，从组件类型和应用角度支持新颖性。采用多种物理化学表征技术对产物进行了表征。EDX-map分析结果显示MOF（Ce）在MOF(Ce)-DCMC-CS结构中分布良好。通过BET验证了该体系的孔隙结构，总孔容为0.061097 cm3/g，平均孔径为7.1189 nm。MOF(Ce)-DCMC-CS对DNR的承载能力和截留效率分别为11.33%和56.66%。令人鼓舞的是，通过Higuchi动力学模型，在pH 5.0条件下，负载DNR的释放率为67.59%，而在pH 6.8和pH 7.4条件下，DNR在72 h内的释放率分别为44.69%和36.71%。体外抗菌研究表明，对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的最低抑菌浓度（MIC）分别为400和800µg/mL。MTT实验结果表明，MOF(Ce)-DCMC-CS具有良好的细胞相容性，但在DNR加载后，其杀伤MDA-MB 231细胞的效率更高，IC50为17.87µg/mL。最终，研究结果表明，开发的MOF(Ce)-DCMC-CS具有作为癌症治疗中的智能药物载体的潜力。图形抽象

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.