Encapsulation of cyclodextrin in polyvinyl alcohol hydrogels for the development of antimicrobial materials for biomedical applications

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2026-10-17 DOI:10.1007/s11172-026-5109-9

A. A. Skuredina, E. Z. Bezhanidze, E. V. Kudryashova

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Abstract

In order to develop a new biomedical material (BM) for treating infections affecting natural barriers of the human body (skin and mucous membranes), this study investigated the effect of the encapsulation of the oligosaccharide cyclodextrin (CD) on the structure of a polyvinyl alcohol (PVA) hydrogel, as well as on the release kinetics and antibacterial activity of a drug molecule, namely fuchsin (FC). FTIR spectroscopy confirmed that CD is integrated into the PVA matrix and is firmly retained within it. The presence of CD increases the rate of FC release from the PVA matrix by a factor of four, making it possible to achieve 100% drug release within 24 h both in a model buffer system and in blood serum. The release of all the encapsulated FC molecules allows the material to achieve its full antibacterial potential, resulting in a four- to fivefold increase in antimicrobial activity against E. coli and B. subtilis strains. The encapsulation of CD in the polymer matrix can facilitate the development of new promising highly effective polymer materials for the treatment of infections arising from bacteria.

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聚乙烯醇水凝胶包封环糊精用于生物医学抗菌材料的开发

为了开发一种新的生物医学材料（BM）来治疗影响人体自然屏障（皮肤和粘膜）的感染，本研究研究了低聚糖环糊精（CD）包封对聚乙烯醇（PVA）水凝胶结构的影响，以及对药物分子品红（FC）的释放动力学和抗菌活性的影响。FTIR光谱证实，CD被整合到PVA矩阵中，并牢固地保留在其中。CD的存在使PVA基质中FC的释放率增加了四倍，使得在模型缓冲系统和血清中24小时内药物释放达到100%成为可能。所有被封装的FC分子的释放使材料能够充分发挥其抗菌潜力，从而使对大肠杆菌和枯草芽孢杆菌菌株的抗菌活性增加四到五倍。将CD包封在聚合物基质中可以促进开发新的有前途的高效聚合物材料，用于治疗细菌引起的感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.