Derivatives of 1,2,4-thiadiazole with an NO-generating moiety

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2026-10-17 DOI:10.1007/s11172-026-5104-1

I. V. Serkov, E. V. Fomina-Ageeva, V. V. Bezuglov, A. N. Proshin

引用次数: 0

Abstract

The synthesis of 1,2,4-thiadiazole derivatives containing a nitroxy or hydroxylimino group as a NO-generating moiety was developed based on the condensation of thiadiazole derivatives containing a keto group with nitroethanolamine and hydroxylamine. The generation of nitric oxide by the synthesized compounds was demonstrated, with the compounds containing a nitroxy group being the most active.

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含no生成基团的1,2,4-噻二唑衍生物

以含酮基的噻二唑衍生物与硝基乙醇胺和羟胺缩合为原料，合成了以硝基或羟基为no生成基团的1,2,4-噻二唑衍生物。合成的化合物可以生成一氧化氮，其中含一个硝基的化合物最活跃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.