The influence of stereochemistry on the biological activity of metal complexes with terpene ligands 1. Antitumor activity of palladium complexes based on l- and d-camphor benzylimines

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2026-10-17 DOI:10.1007/s11172-026-5065-4

Ya. A. Gur’eva, O. A. Zalevskaya, Yu. R. Aleksandrova, I. A. Shagina, M. E. Neganova, A. V. Kutchin

引用次数: 0

Abstract

Enantiomeric pairs of palladium complexes of various types were synthesized using l- and d-camphor benzylimines. The antitumor activity of new palladium complexes and comparison compounds was studied against tumor-derived cells (SH-SY5Y, MCF-7, A549, and SW-480) and non-transformed cells (HEK-293 and DF-1). The interrelation between the stereochemistry and the cytotoxic activity of palladium complexes based on enantiomeric bornane ligands was established. The obtained data confirmed the importance of enantiomeric purity of palladium complexes in the development of candidate antitumor agents with an improved therapeutic profile.

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立体化学对萜烯配体金属配合物生物活性的影响基于l-和d-樟脑苄胺的钯配合物的抗肿瘤活性

利用l-和d-樟脑苄胺合成了不同类型的钯对映体配合物。研究了新型钯配合物和比较化合物对肿瘤源性细胞（SH-SY5Y、MCF-7、A549和SW-480）和非转化细胞（HEK-293和DF-1）的抗肿瘤活性。建立了硼烷对映体钯配合物的立体化学与细胞毒活性之间的相互关系。获得的数据证实了钯配合物的对映体纯度在开发具有改善治疗效果的候选抗肿瘤药物中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.