Prospects for the use of carboxymethylcellulose as a transporter of ruthenium, its compounds, and radionuclides

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2026-10-17 DOI:10.1007/s11172-026-5053-8

M. A. Orlova, V. Yu. Yaryshev, T. P. Trofimova, A. V. Severin, V. V. Spiridonov, A. A. Yaroslavov, S. N. Kalmykov

引用次数: 0

Abstract

Microgels based on carboxymethylcellulose (CMC) containing stable ruthenium ions and ¹⁰⁶Ru isotope were synthesized and characterized by physicochemical and radiochemical methods: double CMC—Ru/¹⁰⁶Ru and triple CMC—Ru—L (L is inducible NO synthase inhibitor or in vivo NO synthase activator). The distribution of these samples in the mice organism was studied, and the times of their complete or partial elimination were estimated. The resulting preparations showed potential for medical use.

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羧甲基纤维素作为钌及其化合物和放射性核素的转运体的前景

本文合成了含有稳定钌离子和106Ru同位素的羧甲基纤维素（CMC）微凝胶，并通过物理化学和放射化学方法对其进行了表征：双CMC - ru /106Ru和三重CMC - ru - L （L为诱导型NO合成酶抑制剂或体内NO合成酶激活剂）。研究了这些样品在小鼠体内的分布，并估计了它们完全或部分消除的时间。由此产生的制剂显示出医疗用途的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.