Green approach in 5-methyl-1-phenyl-2-(1 H)-pyridone synthesis as Pirfenidone active pharmaceutical ingredient

IF 2.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Iranian Chemical Society Pub Date : 2026-10-12 DOI:10.1007/s13738-026-03657-x

Seyyed Jafar Saghanezhad, Amanollah Zarei-Ahmady, Melika Javani, Sedighe Igder, Ali Asghar Hemmati, Mahsa Toolabi, Ali Zohrehbakhsh

引用次数: 0

Abstract

In this study, a green methodology for the preparation of Pirfenidone is reported. In this regard, in the first step, the reaction for the preparation of 5-methylpyridin-2(1 H)-one from 2-amino-5-methylpyridine was performed under acidic reaction conditions via heteropolyacids in the presence of sodium nitrite. In the second step, the reaction was conducted under copper (I) catalysts including supported ionic liquids in the presence of iodobenzene and K₂CO₃. The advantages of this methodology is green and ecofriendly protocol, excellent yield, inexpensive chemicals, facile experimental and work-up procedure.

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绿色途径合成5-甲基-1-苯基-2-(1h)-吡喃酮作为吡非尼酮的活性药物成分

本文报道了一种绿色制备吡非尼酮的方法。为此，第一步在亚硝酸钠存在下，以杂多酸为原料，在酸性条件下由2-氨基-5-甲基吡啶制备5-甲基吡啶-2(1 H)- 1。第二步，在含负载离子液体的铜(I)催化剂下，在碘苯和K2CO3存在下进行反应。该方法具有绿色环保、收率高、化学试剂价格低廉、实验和后处理方便等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.