Transcriptional control of meiotic recombination by DREAM complex components

IF 13.9 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2026-10-16 DOI:10.1126/sciadv.aef2922

Hasibe Tunçay, Xing Ma, Katja Müller, Yuxuan Guo, Valerio Filippo Toccaceli, Huiqi Fu, Franziska Böwer, Lucas Lang, David Latrasse, Yingxiang Wang, Moussa Benhamed, Arp Schnittger

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Abstract

Meiotic chromosome segregation and recombination, essential for sexual reproduction and evolution, require a specialized gene set. Despite its importance, the transcriptional regulators that directly orchestrate meiotic gene expression remain unidentified in plants. We identify the MuvB core components known from the DREAM complex as key transcriptional regulators of meiotic recombination in Arabidopsis. Loss of DREAM components TCX5/6 and ALY1/2 leads to impaired recombination and fertility defects. Meiocyte-specific transcriptome profiling and genome-wide binding analyses reveal that core recombination genes, including the crossover-promoting helicase MER3, are direct targets. Consistently, MER3 overexpression partially rescues recombination defects in DREAM-compromised plants. These findings establish the DREAM complex components as important regulators of the meiotic program in plants. Given that DREAM dysfunction causes reproductive defects in animals, this regulatory role may be conserved across multicellular eukaryotes.

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DREAM复合体组分对减数分裂重组的转录调控

减数分裂染色体的分离和重组是有性生殖和进化所必需的，需要一个专门的基因集。尽管它很重要，但直接协调减数分裂基因表达的转录调节因子在植物中仍未被发现。我们从DREAM复合体中鉴定出MuvB核心组分是拟南芥减数分裂重组的关键转录调控因子。DREAM成分TCX5/6和ALY1/2的缺失导致重组受损和生育缺陷。减数细胞特异性转录组分析和全基因组结合分析表明，核心重组基因，包括促进交叉解旋酶MER3，是直接靶点。一致地，MER3过表达部分地修复了dream受损植物的重组缺陷。这些发现证实了DREAM复合物是植物减数分裂程序的重要调控因子。鉴于DREAM功能障碍导致动物生殖缺陷，这种调节作用可能在多细胞真核生物中保守。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.