Tumor Specific Drug Delivery: Conventional to Advanced Technologies.

IF 2.5 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2026-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2025058329

Adarsh Sharma, Aditya Pratap Singh Thakur, Arya Ojha, Sunny Rathee, Debasis Sen, Sanjay Kumar Jain

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引用次数: 0

Abstract

The treatment of tumors continues to pose significant challenges in modern medicine, necessitating innovative solutions to enhance therapeutic outcomes while reducing side effects. This review focuses on advancements in tumor management, emphasizing the role of novel drug delivery systems (NDDS) in overcoming the limitations of conventional therapies. Traditional approaches are discussed alongside the development of NDDS, including nanoparticle-based systems such as liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles (SLNs), as well as microparticle-based systems like microspheres and microcapsules. Emerging technologies, including cubosomes, exosomes, carbon nanotubes, and quantum dots, are explored for their potential in targeted drug delivery and improved efficacy. Mechanisms of drug release and site-specific targeting are examined, with a particular emphasis on recent innovations and patents in the field. The review provides a forward-looking perspective on the integration of these advancements into clinical practice, aiming to transform the landscape of tumor therapy.

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肿瘤特异性给药：传统到先进技术。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.