Yoga effect on quality of life study among patients with idiopathic pulmonary fibrosis (YES-IPF).

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2026-10-14 DOI:10.1016/j.rmed.2026.109194

Suha Kadura, Soumik Purkayastha, Josh Benditt, Amit Anand, Bridget Collins, Miguele De Quadros, Mafara Hobson, M J Biswas, Lawrence Ho, Cathie Spino, Ganesh Raghu

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引用次数: 0

Abstract

Rationale: Patients with idiopathic pulmonary fibrosis (IPF) have poor health-related quality of life.

Objective: To explore the feasibility and potential impact of a modified yoga program on health-related quality of life in patients with IPF compared with usual care.

Methods: We conducted a randomized, controlled, nonblinded, 12-week pilot clinical trial with two arms involving 63 adults with IPF diagnosed according to the 2018 ATS/ERS/JRS/ALAT clinical practice guideline. The yoga arm attended 1-h virtual group sessions twice weekly for 12 weeks, consisting of seated postures, breathing exercises, and meditation designed for patients with IPF, while the control arm continued usual care.

Measurements: Health-related quality of life was assessed using seven patient-reported outcome measures and their associated domains.

Results: Sixty of 63 randomized participants completed the week-12 assessment and comprised the analysis cohort; their mean age was 73.4 years (SD, 8.2). Statistically significant improvements favoring yoga were seen in the Living with Idiopathic Pulmonary Fibrosis (L-IPF) cough domain (-9.29 points, 95% CI -18.37 to -0.20; p = 0.045; SMD = -0.36), the L-IPF total score (-7.11, 95% CI -13.15 to -1.06; p = 0.022; SMD = -0.38), and the R-scale-PF cough domain (-1.18, 95% CI -2.27 to -0.10; p = 0.034; SMD = -0.45).

Conclusion: In this exploratory pilot trial, a modified yoga program was feasible and well tolerated and was associated with improvements in selected patient-reported outcome domains. These findings are hypothesis-generating and warrant evaluation in a larger, adequately powered trial.

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瑜伽对特发性肺纤维化患者生活质量的影响研究（YES-IPF）。

理由：特发性肺纤维化（IPF）患者的健康相关生活质量较差。目的：探讨与常规护理相比，改良瑜伽方案对IPF患者健康相关生活质量的可行性和潜在影响。方法：我们进行了一项随机、对照、非盲、为期12周的两组临床试验，纳入63名根据2018年ATS/ERS/JRS/ALAT临床实践指南诊断的IPF成人。瑜伽组每周两次参加一小时的虚拟小组会议，持续12周，包括坐姿，呼吸练习和为IPF患者设计的冥想，而对照组继续进行常规护理。测量方法：使用七种患者报告的结果测量方法及其相关领域评估与健康相关的生活质量。结果：63名随机受试者中有60人完成了第12周的评估并组成了分析队列；平均年龄73.4岁（SD, 8.2）。在特发性肺纤维化（L-IPF）咳嗽域（-9.29分，95% CI -18.37至-0.20;p=0.045； SMD=-0.36）、L-IPF总分（-7.11分，95% CI -13.15至-1.06;p=0.022； SMD=-0.38）和R-scale-PF咳嗽域（-1.18分，95% CI -2.27至-0.10;p=0.034； SMD=-0.45）中，瑜伽的改善具有统计学意义。结论：在这个探索性的试点试验中，改进的瑜伽计划是可行的，耐受性良好，并与选定的患者报告的结果领域的改善有关。这些发现是假设的产生，值得在更大的、足够有力的试验中进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.