Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.

IF 3.4 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI:10.1098/rsif.2026.0072

Yanxin Dou, Valerie S T Goh, Thomas Osipowicz, Christelle E L Chua

引用次数: 0

Abstract

High-resolution chromosome imaging plays a key role in understanding chromosome structure. However, traditional methods for super-resolution (<200 nm) chromosome imaging are often complex and time-consuming, requiring purification, staining or sectioning of chromosomes. Here, we propose a novel and simple method to achieve correlative super-resolution imaging for label-free chromosomes through the utilization of the coffee-ring effect. An application of this method is shown to identify dicentric chromosomes and acentric fragments.

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咖啡环效应使无标记染色体的相关超分辨率成像成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of The Royal Society Interface 综合性期刊-综合性期刊

CiteScore

7.10

自引率

2.60%

发文量

234

审稿时长

2.5 months

期刊介绍： J. R. Soc. Interface welcomes articles of high quality research at the interface of the physical and life sciences. It provides a high-quality forum to publish rapidly and interact across this boundary in two main ways: J. R. Soc. Interface publishes research applying chemistry, engineering, materials science, mathematics and physics to the biological and medical sciences; it also highlights discoveries in the life sciences of relevance to the physical sciences. Both sides of the interface are considered equally and it is one of the only journals to cover this exciting new territory. J. R. Soc. Interface welcomes contributions on a diverse range of topics, including but not limited to; biocomplexity, bioengineering, bioinformatics, biomaterials, biomechanics, bionanoscience, biophysics, chemical biology, computer science (as applied to the life sciences), medical physics, synthetic biology, systems biology, theoretical biology and tissue engineering.