Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.

IF 3.4 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI:10.1098/rsif.2026.0187

Mitchel J Colebank, Alfonso Limon, Anthony Chang, Brandon Wong, Wyman Lai, Hamilton Baker

{"title":"Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.","authors":"Mitchel J Colebank, Alfonso Limon, Anthony Chang, Brandon Wong, Wyman Lai, Hamilton Baker","doi":"10.1098/rsif.2026.0187","DOIUrl":null,"url":null,"abstract":"<p><p>Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively few studies have built computer models for VSD, nor have they considered how natural adaptation to the cardiovascular system with age might interact with the presence of a small-, medium- or large-sized VSD. Here, we combine a lumped-parameter model of the cardiovascular system with two key modelling components: a size-dependent resistance dictating shunt flow between the two ventricles and age-dependent scaling relationships for the systemic and pulmonary circulations. Our results provide insight into changes in haemodynamic conditions with various VSD sizes. We investigate the combined effects of VSD size, vascular parameters and age, showing distinct differences with these three factors. This study lays the necessary foundation for studying VSD and towards building digital shadows and digital twins for managing VSD in paediatrics.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Royal Society Interface","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rsif.2026.0187","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively few studies have built computer models for VSD, nor have they considered how natural adaptation to the cardiovascular system with age might interact with the presence of a small-, medium- or large-sized VSD. Here, we combine a lumped-parameter model of the cardiovascular system with two key modelling components: a size-dependent resistance dictating shunt flow between the two ventricles and age-dependent scaling relationships for the systemic and pulmonary circulations. Our results provide insight into changes in haemodynamic conditions with various VSD sizes. We investigate the combined effects of VSD size, vascular parameters and age, showing distinct differences with these three factors. This study lays the necessary foundation for studying VSD and towards building digital shadows and digital twins for managing VSD in paediatrics.

查看原文本刊更多论文

孤立性室间隔缺损儿童血流动力学的数学模拟。

心血管系统的计算机建模有可能彻底改变个性化医疗保健。这对于先天性心脏缺陷尤其有希望，如室间隔缺损（VSD），心脏两个心室之间的一个洞。然而，相对较少的研究建立了室性室间隔的计算机模型，也没有考虑到随着年龄对心血管系统的自然适应如何与小、中、大室性室间隔的存在相互作用。在这里，我们将心血管系统的集总参数模型与两个关键建模组件相结合：决定两个心室之间分流流的大小相关阻力和系统循环和肺循环的年龄相关缩放关系。我们的研究结果为不同室间隔大小的血流动力学条件的变化提供了见解。我们研究了室间隔大小、血管参数和年龄的综合影响，发现这三个因素存在明显差异。本研究为进一步研究室间隔缺损，建立儿科室间隔缺损的数字阴影和数字孪生奠定了必要的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of The Royal Society Interface 综合性期刊-综合性期刊

CiteScore

7.10

自引率

2.60%

发文量

234

审稿时长

2.5 months

期刊介绍： J. R. Soc. Interface welcomes articles of high quality research at the interface of the physical and life sciences. It provides a high-quality forum to publish rapidly and interact across this boundary in two main ways: J. R. Soc. Interface publishes research applying chemistry, engineering, materials science, mathematics and physics to the biological and medical sciences; it also highlights discoveries in the life sciences of relevance to the physical sciences. Both sides of the interface are considered equally and it is one of the only journals to cover this exciting new territory. J. R. Soc. Interface welcomes contributions on a diverse range of topics, including but not limited to; biocomplexity, bioengineering, bioinformatics, biomaterials, biomechanics, bionanoscience, biophysics, chemical biology, computer science (as applied to the life sciences), medical physics, synthetic biology, systems biology, theoretical biology and tissue engineering.