Paola Roggero, Francesca Giuliani, Robert B Gunier, Adele Winsey, Stephen A Rauch, Montserrat Izquierdo Renau, Irma Alejandra Coronado Zarco, Shabina Ariff, Maria Albertina S Rego, Constanza Soto Conti, Roseline Ochieng, Funda Tuzun, Jacqueline Asibey, Chandrakala Bada Shekharappa, Alexandre Lapillonne, Gabriela Tavcioska, Leila Cheikh Ismail, Camilla Menis, Marina Markelova, Ricardo Nieto, Josephine N A Agyeman-Duah, Sonia Deantoni, Brenda Frias Madrid, Fabio Mosca, Irina Ryumina, Monica Fumagalli, Brenda Eskenazi, Zulfiqar Bhutta, Aris Papageorghiou, Stephen Kennedy, Jose Villar
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引用次数: 0
Abstract
Objective: Compare birth size and postnatal growth between preterm twins and singletons across gestational age categories and etiologic subgroups.
Study design: Preterm twins and singletons (n = 3245) were classified into nine subgroups based on predefined preterm birth etiologies. Postnatal growth (weight, length and head circumference) trajectories were evaluated using multilevel linear regression models accounting for repeated measurements, expressed as z-score changes from birth to hospital discharge based on INTERGROWTH-21st Standards.
Results: Twins were significantly smaller at birth than singletons, particularly in late preterm category, but not in the very preterm category. Twin postnatal growth was slower (unadjusted models); most differences attenuated or reversed after adjusting for birth size and key covariates. Twins in the 'pre-eclampsia' subgroup showed greater adjusted postnatal weight, whereas weight gain was persistently lower in the 'perinatal sepsis' subgroup.
Conclusion: Preterm twins and singletons have distinct intrauterine and postnatal growth patterns, varying by preterm birth etiology and gestational age categories.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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