Urinary Extracellular Vesicle–Associated EphA2 Predicts Intravesical Recurrence in Bladder Cancer

IF 2.9 3区医学 Q3 UROLOGY & NEPHROLOGY

International Journal of Urology Pub Date : 2026-10-13 DOI:10.1111/iju.70656

Mamoru Hashimoto, Eisuke Tomiyama, Lan Inoki, Koji Miki, Takahito Nakayama, Saizo Fujimoto, Shingo Toyoda, Takashi Kikuchi, Ryo Ukekawa, Yutaka Yamamoto, Takafumi Minami, Kazuhiro Yoshimura, Norio Nonomura, Kazutoshi Fujita

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引用次数: 0

Abstract

Objective

To examine the clinical usefulness of EphA2 detected on urinary extracellular vesicles (uEphA2) for bladder cancer detection and for estimating the risk of intravesical recurrence after transurethral resection of bladder tumor (TURBT).

Methods

An enzyme-linked immunosorbent assay was established to measure EphA2-positive urinary extracellular vesicles. The diagnostic cohort comprised 191 participants, including 120 patients with bladder cancer and 71 controls.

Results

uEphA2 concentrations were higher in patients with bladder cancer than in controls. Receiver operating characteristic analysis yielded an area under the curve of 0.679, with 46.7% sensitivity and 87.3% specificity. Among patients evaluable for post-TURBT recurrence, high uEphA2 levels were associated with shorter intravesical recurrence-free survival. This association remained significant in multivariable Cox regression analysis after adjustment for the EORTC risk score and age.

Conclusions

uEphA2 showed modest diagnostic accuracy but high specificity and was independently associated with intravesical recurrence. These results support its potential use as a non-invasive urinary marker for post-TURBT risk stratification.

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尿细胞外囊泡相关EphA2预测膀胱癌膀胱内复发

目的：探讨尿细胞外囊泡（uEphA2）检测EphA2在膀胱癌检测及经尿道膀胱肿瘤切除术（TURBT）后膀胱内复发风险评估中的临床价值。方法：采用酶联免疫吸附法检测epha2阳性尿细胞外囊泡。诊断队列包括191名参与者，其中包括120名膀胱癌患者和71名对照组。结果：膀胱癌患者的uEphA2浓度高于对照组。受试者工作特征分析曲线下面积为0.679，敏感性46.7%，特异性87.3%。在可评估turt后复发的患者中，高uEphA2水平与较短的膀胱内无复发生存期相关。在调整了EORTC风险评分和年龄后，这种关联在多变量Cox回归分析中仍然显著。结论：uEphA2诊断准确性不高，但特异性高，且与膀胱内复发独立相关。这些结果支持其作为turt后风险分层的非侵入性尿标志物的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Urology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

11.50%

发文量

340

审稿时长

3 months

期刊介绍： International Journal of Urology is the official English language journal of the Japanese Urological Association, publishing articles of scientific excellence in urology. Submissions of papers from all countries are considered for publication. All manuscripts are subject to peer review and are judged on the basis of their contribution of original data and ideas or interpretation.