Allergic load and symptom severity in children with tic disorders: a cross-sectional study.

IF 2.9 3区医学 Q1 PEDIATRICS

European Journal of Pediatrics Pub Date : 2026-10-13 DOI:10.1007/s00431-026-07510-4

Duan Lin, Jiqiang Xie, Liangliang Chen, Yanting Lu, Yajun Tang, Xiumei Liu

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引用次数: 0

Abstract

Tic disorders (TD) are associated with allergies, but the immune mechanisms and their impact on tic severity remain unclear. This study examined the immune profile in children with comorbid TD and allergic diseases (AD) to explore the graded association between allergic load index and tic severity. A total of 136 children with TD (aged 4 - 13 years) were divided into TD (n = 76) and TD + AD (n = 60) groups. Serum IgE levels were measured, tic severity was assessed by the Yale Global Tic Severity Scale (YGTSS), and a composite allergic load index was constructed. Its graded association with the YGTSS total tic score (0 - 50) was analyzed using correlation, trend, and regression methods. Compared with the TD group, the TD + AD group showed significantly greater vocal tic number, functional impairment, tIgE positivity, tIgE levels, sIgE positivity, and number of positive sIgE items (all p < 0.05). The moderate-to-severe tic group showed elevated positivity of allergic markers and more allergic diseases than the minimal/mild groups (p < 0.05). A graded association was observed, with each one‑standard‑deviation increase in the allergic load index corresponding to a 2.66‑point higher YGTSS total tic score (p < 0.001).

Conclusion: The allergic load index was positively associated with tic severity, showing a graded relationship. Systematic assessment of allergic status may provide clinically useful information in the evaluation of children with TD.

What is known: • Tic disorders (TD) and allergic diseases (AD) frequently co-occur in children. • Elevated IgE levels and Th2 immune bias have been observed in both conditions.

What is new: • Allergic load index, a composite measure integrating IgE levels, sIgE count, and allergic disease count, shows a graded positive association with tic severity in children with TD. • Each one‑standard‑deviation increase in the index corresponds to a 2.66‑point higher YGTSS total tic score.

查看原文本刊更多论文

抽动障碍儿童的过敏负荷和症状严重程度：一项横断面研究。

抽动障碍（TD）与过敏有关，但免疫机制及其对抽动严重程度的影响尚不清楚。本研究检测了并发TD和过敏性疾病（AD）儿童的免疫特征，以探讨过敏负荷指数与抽动严重程度之间的分级关系。136例4 ~ 13岁的TD患儿分为TD组（n = 76）和TD + AD组（n = 60）。测定血清IgE水平，采用耶鲁全球抽动严重程度量表（YGTSS）评估抽动严重程度，并构建复合过敏负荷指数。使用相关、趋势和回归方法分析其与YGTSS总tic评分（0 - 50）的分级相关性。与TD组比较，TD + AD组的抽动次数、功能损害、tIgE阳性、tIgE水平、sIgE阳性、sIgE阳性项数均显著高于TD组(p)。结论：过敏负荷指数与抽动严重程度呈正相关，呈分级关系。系统评估过敏状态可能为评估儿童TD提供临床有用的信息。•抽动障碍（TD）和过敏性疾病（AD）经常在儿童中同时发生。•在两种情况下均观察到IgE水平升高和Th2免疫偏倚。新发现：•过敏负荷指数是一种综合IgE水平、sIgE计数和过敏性疾病计数的综合指标，显示与TD患儿抽动严重程度呈分级正相关。•指数每增加一个标准差，YGTSS总分就增加2.66分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pediatrics 医学-小儿科

CiteScore

5.90

自引率

2.80%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The European Journal of Pediatrics (EJPE) is a leading peer-reviewed medical journal which covers the entire field of pediatrics. The editors encourage authors to submit original articles, reviews, short communications, and correspondence on all relevant themes and topics. EJPE is particularly committed to the publication of articles on important new clinical research that will have an immediate impact on clinical pediatric practice. The editorial office very much welcomes ideas for publications, whether individual articles or article series, that fit this goal and is always willing to address inquiries from authors regarding potential submissions. Invited review articles on clinical pediatrics that provide comprehensive coverage of a subject of importance are also regularly commissioned. The short publication time reflects both the commitment of the editors and publishers and their passion for new developments in the field of pediatrics. EJPE is active on social media (@EurJPediatrics) and we invite you to participate. EJPE is the official journal of the European Academy of Paediatrics (EAP) and publishes guidelines and statements in cooperation with the EAP.